Azelastine Hydrochloride EP Impurity C CAS 53242-76-5
| CAS No. | 53242-76-5 |
| Molecular Formula | C15H11ClO3 |
| Molecular Weight | 274.70 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Azelastine Hydrochloride EP Impurity C (CAS 53242-76-5, C15H11ClO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Azelastine Hydrochloride EP Impurity C (C15H11ClO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C15H11ClO3 |
| Molecular Weight | 274.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | Cl-containing |
Related Azelastine Standards
- Azelastine Impurity 45 (CAS 148960-78-5)
- Azelastine Impurity 47 (CAS CATO-C4X-139647)
- Azelastine Impurity 13 (CAS 791758-74-2)
- Azelastine Impurity 67 (CAS CATO-C4X-139667)
- Azelastine Impurity 68 (CAS CATO-C4X-139668)
- Azelastine EP Impurity D (CAS 53242-88-9)
- Azelastine impurity 58 (CAS CATO-C4X-139658)
- Azelastine EP Impurity E (Z-Isomer) (CAS 105279-16-1)
Recommended Standards
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- N-((1H-imidazol-2-yl)methyl)-2,3-dihydro-1H-inden-5-amine (CAS 1250114-57-8)
- 5-ethyl-2-pyridinecarbohydrazide (CAS 19842-04-7)
- Fibrinogen Related Peptide (CAS 80755-86-8)
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