Promethazine lmpurity 31 CAS 53309-35-6
| CAS No. | 53309-35-6 |
| Molecular Formula | C5H12ClN |
| Molecular Weight | 121.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 121.61 g/mol gives Promethazine lmpurity 31 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Promethazine lmpurity 31 (CAS 53309-35-6) is a certified pharmaceutical impurity reference standard with the molecular formula C5H12ClN and a molecular weight of 121.61 g/mol.
The molecular framework of Promethazine lmpurity 31 (C5H12ClN) is characterized by chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H12ClN |
| Molecular Weight | 121.61 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 0.0 |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Promethazine Standards
- Promethazine Impurity 5 (CAS 108-14-5)
- Promethazine Impurity 57 (CAS 75411-83-5)
- Promethazine Impurity 68 (CAS 121861-55-0)
- Promethazine Impurity 24 (CAS 1070758-14-3)
- Promethazine Impurity 72 (CAS 409314-72-3)
- Promethazine Impurity 56 (CAS CATO-C4X-141856)
- Promethazine Impurity 71 (CAS CATO-C4X-141871)
- Promethazine Impurity 11 (CAS 108-16-7)
Recommended Standards
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- Hydroxychloroquine Impurity 46 (CAS CATO-C4X-183546)
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- Strontium hydroxide (CAS 18480-07-4)
- Relugoli Impurity 138 (CAS CATO-C4X-2429138)
- Epinastine Impurity 51 (CAS CATO-C4X-184051)
- Amoxicillin Impurity 63 (CAS CATO-C4X-114863)
- 4-Bromo-6-(difluoromethyl)-3-methoxypicolinonitrile (CAS 1805438-95-2)
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- (S)-2,2'-Bis(bromomethyl)-1,1'-binaphthalene, 95% (99% ee) (CAS 37803-02-4)
- Vinylphosphonic Acid (CAS 1746-03-8)
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- [Glu]17-Semaglutide (CAS CATO-CPTD788604)
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