Erlotinib Impurity 87 CAS CATO-C4X-106987
| CAS No. | CATO-C4X-106987 |
| Molecular Formula | C8H8BrN |
| Molecular Weight | 198.06 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Erlotinib Impurity 87.
As a process- or degradation-related impurity, Erlotinib Impurity 87 (CAS CATO-C4X-106987, C8H8BrN) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Erlotinib Impurity 87 (C8H8BrN) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8BrN |
| Molecular Weight | 198.06 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Erlotinib Standards
- Erlotinib Impurity 123 (CAS 1145671-36-8)
- Erlotinib impurity 130 (CAS 585-79-5)
- Erlotinib Impurity 112 (CAS 555-68-0)
- Erlotinib Impurity 105 (CAS 33432-52-9)
- Erlotinib Impurity 61 (CAS 20825-87-0)
- Erlotinib Impurity 78 (CAS 174674-93-2)
- Erlotinib Impurity 79 (CAS 382150-30-3)
- Erlotinib Impurity 84 (CAS 16064-15-6)
Recommended Standards
- 5-Bromoisoindoline (CAS 127168-84-7)
- 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)butan-2-one (CAS 100818-32-4)
- 7-Bromoindoline (CAS 62813-85-8)
- (Z)-(4-Hydroxy-2-buten-2-yl)boronic Acid Pinacol Ester (CAS 1008752-03-1)
- Leuprorelin EP Impurity E Acetate (CAS CATO-C4X-18225)
- Thiamine Impurity 15 (CAS 24941-82-0)
- Iobitridol Impurity 13 (CAS CATO-C4X-317813)
- Benzyl-2,3,4,5,6-d5 Bromide (CAS 71258-22-5)
- 3-(4-Hydroxymethylphenyl)picolinic acid (CAS 1261896-71-2)
- Methyl 3-hydroxy-2-nitrosopent-2-enoate (CAS 1937358-65-0)
- N-(2-methyl-6-(pyrrolidin-3-yl)pyridin-4-yl)pyrimidin-2-amine (CAS 1361114-81-9)
- 6-Amino-1-(3-fluorophenyl)pyrimidine-2,4(1H,3H)-dione (CAS 18464-28-3)
- 2-(Difluoromethyl)-5-hydroxy-3-(trifluoromethoxy)pyridine-6-carboxaldehyde (CAS 1804725-70-9)
- Galanin-Like Peptide (rat) trifluoroacetate salt (CAS 245114-97-0)
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