Nicotinamide Impurity 9 CAS 536-33-4

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.536-33-4
Molecular FormulaC8H10N2S
Molecular Weight166.24 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Nicotinamide Impurity 9 CAS 536-33-4 chemical structure

Description

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

As a process- or degradation-related impurity, Nicotinamide Impurity 9 (CAS 536-33-4, C8H10N2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

Nicotinamide Impurity 9 (C8H10N2S) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality. Its physicochemical properties are representative of its class; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

Physical & Chemical Properties

Molecular FormulaC8H10N2S
Molecular Weight166.24 g/mol
Purity97%+
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityLight-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)5.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1957
Nitrogen Atoms2
Sulfur Atoms1

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