Nicotinamide Impurity 8 CAS 4314-66-3
| CAS No. | 4314-66-3 |
| Molecular Formula | C8H10N2O |
| Molecular Weight | 150.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Nicotinamide Impurity 8 (CAS 4314-66-3, C8H10N2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Nicotinamide Impurity 8 (C8H10N2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 150.18 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C8H10N2O |
| Molecular Weight | 150.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 2 |
Related Nicotinamide Standards
- Nicotinamide-d4 N-Oxide_x0000_ (d4 Major) (CAS 1246817-64-0)
- Nicotinamide 1-Methyl 1,4-Dihydro Impurity (CAS 17750-23-1)
- Nicotinamide impurity 19 (CAS CATO-C4X-200019)
- Nicotinamide EP Impurity E (CAS 1986-81-8)
- Nicotinamide Impurity 6 (CAS 6960-22-1)
- Nicotinamide Impurity 7 (CAS 114-33-0)
- Nicotinamide impurity 24 (CAS CATO-C4X-200024)
- Nicotinamide Impurity 9 (CAS 536-33-4)
Recommended Standards
- Prilocaine impurity 60 (CAS CATO-C4X-193460)
- 3,5,6-Trimethylpyrazine-2-carbaldehyde (CAS 186534-02-1)
- Nikethamide Impurity 9 (CAS 41116-48-7)
- N-Nitroso-N-Ethylaniline (CAS 612-64-6)
- Empagliflozin impurity 237 (CAS CATO-C4X-1065237)
- Thymalfasin Impurity 9 (CAS CATO-C4X-18989)
- Relugolix Impurity 74 (CAS CATO-C4X-242974)
- 6-Chloro-2-(difluoromethyl)-5-nitronicotinaldehyde (CAS 1805270-63-6)
- 1-(2-methyl-6-nitrophenyl)ethan-1-one (CAS 4127-55-3)
- n-[(1-benzyl-3,5-dimethyl-1h-pyrazol-4-yl)methylidene]hydroxylamine (CAS 1375476-93-9)
- 2-(Benzo[d][1,3]dioxol-5-yl)-2-(dimethylamino)acetic acid (CAS 1103977-07-6)
- Ethyl 2-ethoxy-5-iodobenzoate (CAS 1131587-17-1)
- Prulifloxacin (CAS 123447-63-2)
- Semaglutide Impurity 183 (CAS 159541-28-3)
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