Rivaroxaban Impurity 135 CAS 53935-71-0
| CAS No. | 53935-71-0 |
| Molecular Formula | C5H3ClO2S |
| Molecular Weight | 162.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 162.59 g/mol gives Rivaroxaban Impurity 135 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Rivaroxaban Impurity 135 (CAS 53935-71-0) is a certified pharmaceutical impurity reference standard with the molecular formula C5H3ClO2S and a molecular weight of 162.59 g/mol.
Owing to a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, Rivaroxaban Impurity 135 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 162.59 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Rivaroxaban Impurity 135 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C5H3ClO2S |
| Molecular Weight | 162.59 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Rivaroxaban Standards
- Rivaroxaban Impurity 136 (CAS 36157-42-3)
- Rivaroxaban Impurity 21 (CAS 59337-89-2)
- Rivaroxaban EP Impurity F (CAS 24065-33-6)
- Rivaroxaban Impurity 90 (CAS 59614-95-8)
- Rivaroxaban Impurity 114 (CAS 22353-82-8)
- Rivaroxaban impurity 194 (CAS CATO-C4X-1090194)
- Rivaroxaban Impurity 45 (CAS 6310-09-4)
- Rivaroxaban Impurity 25 (CAS 2648-71-7)
Recommended Standards
- 2-chloro-3-fluoropyridine-4-carbonitrile (CAS 870065-56-8)
- 2-Chloro-1-(3-fluorobicyclo[1.1.1]pentan-1-yl)ethan-1-one (CAS 2452341-37-4)
- 3-(Chloromethyl)-1-(2-fluoroethyl)-1h-pyrazole (CAS 1429418-90-5)
- 5-(Chloromethyl)-1-(2-fluoroethyl)-1h-pyrazole (CAS 1429418-42-7)
- Octreotide Impurity 31 (CAS CATO-C4X-152031)
- Isavuconazole impurity 73 (CAS CATO-C4X-1236173)
- Hydrochlorothiazide Impurity 7 (CAS CATO-C4X-11777)
- (4-Amino-1-(p-tolyl)-1H-imidazol-5-yl)(phenyl)methanone (CAS 304871-19-0)
- Ethyl acrylate-methacrylic acid-methyl methacrylate copolymer (CAS 25133-97-5)
- (2S)-2-(aminomethyl)-3-hydroxy-propanoic acid (2S)-2-(aminomethyl)-3-hydroxy-propionic acid (2S)-2-(aminomethyl)-3-hydroxypropanoic acid (2S)-2-(aminomethyl)-3-oxidanyl-propanoic acid (S)-3-amino-2-(hydroxymethyl)propanoic acid 930784-11-5 (CAS 930784-11-5)
- N-Hydroxy-adamantane-1-carboxamidine (CAS 53658-91-6)
- Lumateperone Impurity N2 (CAS 313544-31-9)
- 3,4,5-Trichloropyridin-2-amine (CAS 55933-91-0)
- Semaglutide impurity 70 (CAS CATO-C4X-222670)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com