Rivaroxaban Impurity 114 CAS 22353-82-8
| CAS No. | 22353-82-8 |
| Molecular Formula | C5H4ClNOS |
| Molecular Weight | 161.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Rivaroxaban Impurity 114 (CAS 22353-82-8, C5H4ClNOS) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution, Rivaroxaban Impurity 114 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 161.61 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H4ClNOS |
| Molecular Weight | 161.61 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Rivaroxaban Standards
- Rivaroxaban impurity 194 (CAS CATO-C4X-1090194)
- Rivaroxaban Impurity 135 (CAS 53935-71-0)
- Rivaroxaban Impurity 136 (CAS 36157-42-3)
- Rivaroxaban Impurity 21 (CAS 59337-89-2)
- Rivaroxaban EP Impurity F (CAS 24065-33-6)
- Rivaroxaban Impurity 90 (CAS 59614-95-8)
- Rivaroxaban Impurity 45 (CAS 6310-09-4)
- Rivaroxaban Impurity 25 (CAS 2648-71-7)
Recommended Standards
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- 5,7,2’,6’-Tetrahydroxyflavone (CAS 82475-00-1)
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