Rivaroxaban Impurity 136 CAS 36157-42-3
| CAS No. | 36157-42-3 |
| Molecular Formula | C5H3ClO2S |
| Molecular Weight | 162.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Rivaroxaban Impurity 136 (CAS 36157-42-3), a pharmacopoeial impurity reference standard (molecular formula C5H3ClO2S, MW 162.59 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Rivaroxaban Impurity 136 (C5H3ClO2S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C5H3ClO2S |
| Molecular Weight | 162.59 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Rivaroxaban Standards
- Rivaroxaban Impurity 135 (CAS 53935-71-0)
- Rivaroxaban Impurity 21 (CAS 59337-89-2)
- Rivaroxaban EP Impurity F (CAS 24065-33-6)
- Rivaroxaban Impurity 90 (CAS 59614-95-8)
- Rivaroxaban Impurity 114 (CAS 22353-82-8)
- Rivaroxaban impurity 194 (CAS CATO-C4X-1090194)
- Rivaroxaban Impurity 45 (CAS 6310-09-4)
- Rivaroxaban Impurity 25 (CAS 2648-71-7)
Recommended Standards
- 2-chloro-3-fluoropyridine-4-carbonitrile (CAS 870065-56-8)
- 2-Chloro-1-(3-fluorobicyclo[1.1.1]pentan-1-yl)ethan-1-one (CAS 2452341-37-4)
- 3-(Chloromethyl)-1-(2-fluoroethyl)-1h-pyrazole (CAS 1429418-90-5)
- 5-chloro-1,3-thiazole-4-carboxamide (CAS 1006047-44-4)
- Tigecycline Impurity 7 (CAS 1268494-40-1)
- Methotrexate Impurity 34 (CAS CATO-C4X-115434)
- Fingolimod EP Impurity A (CAS 1201794-93-5)
- Methyl 6-aminospiro[3.3]heptane-2-carboxylate Hydrochloride (CAS 1808249-67-3)
- 5-(4-Bromophenyl)-4-(3,5-dimethylphenyl)-4H-1,2,4-triazole-3-thiol (CAS 380345-94-8)
- N-((2,2-diethoxyethyl)carbamoyl)-6-methoxynicotinamide (CAS 240799-46-6)
- Band 3 Protein (824-829) (human) H-Tyr-Val-Lys-Arg-Val-Lys-OH (CAS 158475-15-1)
- 1-(2-Methylpropoxy)propan-2-amine hydrochloride (CAS 1240529-05-8)
- Polymyxin Impurity 36 TFA (CAS CATO-C4X-225536)
- Atrial Natriuretic Peptide (ANP)(1-28) Alpha (Human, Ovine, Canine) (CAS 91917-63-4)
Why CATO?
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