2,5-bis(chloromethyl)-1,3,4-oxadiazole CAS 541540-90-3
| CAS No. | 541540-90-3 |
| Molecular Formula | C4H4Cl2N2O |
| Molecular Weight | 166.99 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2,5-bis(chloromethyl)-1,3,4-oxadiazole (CAS 541540-90-3) is a high-purity analytical reference standard with the molecular formula C4H4Cl2N2O and a molecular weight of 166.99 g/mol.
The molecular framework of 2,5-bis(chloromethyl)-1,3,4-oxadiazole (C4H4Cl2N2O) is characterized by an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 2,5-bis(chloromethyl)-1,3,4-oxadiazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H4Cl2N2O |
| Molecular Weight | 166.99 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related bis Standards
- 3,5-Bis(chloromethyl)-1,2,4-oxadiazole (CAS 1194-01-0)
- (Chloromethyl)dimethylisopropoxysilane (Chloromethyl)isopropoxydimethylsilane 18171-11-4 C1370 (CAS 18171-11-4)
- (Chloromethyl)dimethoxy(vinyl)silane (CAS 1314981-48-0)
- 2-(Chloromethyl)-2,3-dihydro-1h-indene (CAS 1260801-96-4)
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- 1-(Chloromethyl)-2,3-dihydro-1h-indene (CAS 90320-62-0)
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Recommended Standards
- 1,1-Cyclopropanedicarbonyl dichloride (CAS 34782-60-0)
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- Methyl (3S,5S)-5-methylpiperidine-3-carboxylate (CAS 405513-13-5)
- 6-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid (CAS 1227270-51-0)
- Semaglutide impurity 95 (CAS CATO-C4X-222695)
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