Apremilast Impurity 67 CAS 5434-20-8
| CAS No. | 5434-20-8 |
| Molecular Formula | C8H7NO4 |
| Molecular Weight | 181.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Apremilast Impurity 67 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Apremilast Impurity 67 (CAS 5434-20-8), a pharmacopoeial impurity reference standard (molecular formula C8H7NO4, MW 181.15 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Apremilast Impurity 67 (C8H7NO4) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 181.15 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C8H7NO4 |
| Molecular Weight | 181.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 1 |
Related Apremilast Standards
- Apremilast Impurity 110 (CAS 34184-93-5)
- Apremilast Impurity 108 (CAS 120-25-2)
- Apremilast Impurity 66 (CAS 587-48-4)
- Apremilast Impurity 57 (CAS 3096-76-2)
- Apremilast Impurity 80 (CAS 60758-86-3)
- Apremilast Impurity 109 (CAS 2029-94-9)
- Apremilast Impurity 86 (CAS 106860-70-2)
- Apremilast Impurity 18 (CAS 51673-94-0)
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- 5-Cyclopropoxy-2-nitronicotinamide (CAS 1243398-06-2)
- (3-(1-Ethoxyethyl)-1,2,4-oxadiazol-5-yl)methanamine (CAS 1339660-12-6)
- 3-Iodo-5-nitropyridin-4-ol (CAS 1072140-97-6)
- Semaglutide (CAS 910463-68-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com