Apremilast Impurity 80 CAS 60758-86-3
| CAS No. | 60758-86-3 |
| Molecular Formula | C10H11NO2 |
| Molecular Weight | 177.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C10H11NO2, Apremilast Impurity 80 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 177.20 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Apremilast Impurity 80 (CAS 60758-86-3, C10H11NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H11NO2 |
| Molecular Weight | 177.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
| Nitrogen Atoms | 1 |
Related Apremilast Standards
- Apremilast Impurity 57 (CAS 3096-76-2)
- Apremilast Impurity 66 (CAS 587-48-4)
- Apremilast Impurity 108 (CAS 120-25-2)
- Apremilast Impurity 67 (CAS 5434-20-8)
- Apremilast Impurity 110 (CAS 34184-93-5)
- Apremilast Impurity 18 (CAS 51673-94-0)
- Apremilast Impurity 111 (CAS 60758-79-4)
- Apremilast Impurity 68 (CAS 17395-99-2)
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