Fluorouracil Impurity 17 CAS 5440-00-6
| CAS No. | 5440-00-6 |
| Molecular Formula | C6H10N4O2 |
| Molecular Weight | 170.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Fluorouracil Impurity 17.
Fluorouracil Impurity 17 (CAS 5440-00-6) is a certified pharmaceutical impurity reference standard with the molecular formula C6H10N4O2 and a molecular weight of 170.17 g/mol.
The molecular framework of Fluorouracil Impurity 17 (C6H10N4O2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Fluorouracil Impurity 17 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H10N4O2 |
| Molecular Weight | 170.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 4 |
Related Fluorouracil Standards
- Fluorouracil Impurity 27 (CAS 2566704-13-8)
- Fluorouracil Impurity 18 (CAS CATO-C4X-164918)
- Fluorouracil Impurity 23 (CAS CATO-C4X-164923)
- Fluorouracil Impurity 29 (CAS CATO-C4X-164929)
- Fluorouracil Impurity 8 (CAS 726207-85-8)
- Fluorouracil EP Impurity F (CAS 56177-80-1)
- Fluorouracil Impurity N2 (CAS 55996-26-4)
- Fluorouracil Impurity 28 (CAS CATO-C4X-164928)
Recommended Standards
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- Vonoprazan Fumarate Impurity 111 (CAS 928325-69-3)
- Glycopyrronium Bromide Impurity 14 (CAS CATO-C4X-181714)
- Baloxavir Marboxil Impurity 196 (CAS CATO-C4X-2108196)
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