2,4-Dichlorobenzyl Alcohol EP Impurity D CAS 5468-96-2
| CAS No. | 5468-96-2 |
| Molecular Formula | C9H8Cl2O2 |
| Molecular Weight | 219.06 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, 2,4-Dichlorobenzyl Alcohol EP Impurity D (CAS 5468-96-2, C9H8Cl2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
2,4-Dichlorobenzyl Alcohol EP Impurity D (C9H8Cl2O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H8Cl2O2 |
| Molecular Weight | 219.06 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
Related Dichlorobenzyl Standards
- N-(2,5-Dichlorobenzyl)propan-2-amine (CAS 1152879-31-6)
- 2,4-Dichlorobenzyl isothiocyanate (CAS 18967-41-4)
- 3,4-Dichlorobenzyl isothiocyanate (CAS 18967-42-5)
- 3,4-Dichlorobenzyl thiocyanate (CAS 2082-67-9)
- N-(3,4-dichlorobenzyl)acetamide (CAS 53313-32-9)
- 2-((3,5-Dichlorobenzyl)amino)ethan-1-ol (CAS 1183137-67-8)
- 2-((2,5-Dichlorobenzyl)amino)ethanol (CAS 1353981-56-2)
- N-(3,4-dichlorobenzyl)-O-ethylhydroxylamine (CAS 1457472-77-3)
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- 2-((3-(Diethylamino)quinoxalin-2-yl)thio)acetic acid (CAS 893725-58-1)
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- 2-(Allyloxy)isonicotinonitrile (CAS 1092299-44-9)
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