Guanfacine Hydrochloride Impurity 1 CAS 54551-83-6
| CAS No. | 54551-83-6 |
| Molecular Formula | C9H8Cl2O2 |
| Molecular Weight | 219.06 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Guanfacine Hydrochloride Impurity 1 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Guanfacine Hydrochloride Impurity 1 (CAS 54551-83-6) is a certified pharmaceutical impurity reference standard with the molecular formula C9H8Cl2O2 and a molecular weight of 219.06 g/mol.
Based on its molecular formula C9H8Cl2O2, Guanfacine Hydrochloride Impurity 1 contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 219.06 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Guanfacine Hydrochloride Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H8Cl2O2 |
| Molecular Weight | 219.06 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | Cl-containing |
Related Guanfacine Standards
- Guanfacine Hydrochloride Impurity 4 (CAS 57486-36-9)
- Guanfacine Hydrochloride Impurity 3 (CAS 6575-24-2)
- Guanfacine Impurity 6 (CAS 90793-64-9)
- Guanfacine Hydrochloride Impurity 2 (CAS 78433-88-2)
- Guanfacine Impurity 4 (CAS 78622-22-7)
- Guanfacine-13C,15N3 (CAS 1189924-28-4)
- Guanfacine Impurity 13 (CAS 130974-86-6)
- Guanfacine Impurity 10 (CAS 24067-37-6)
Recommended Standards
- 2,4-Dichlorobenzyl Alcohol EP Impurity D (CAS 5468-96-2)
- Piribedil Impurity 4 (CAS CATO-C4X-28134)
- Roxatidine Impurity 48 (CAS 4530-45-4)
- 2-(2,5-Dichlorophenoxy)acetimidamide (CAS 1001567-19-6)
- Cetirizine EP Impurity D (CAS 346451-15-8)
- Dotinurad Impurity 141 (CAS CATO-C4X-2494141)
- Acotiamide Impurity 26 (CAS 185105-98-0)
- 2,4,9,11-tetraethyl-3,6,10,13-tetraoxapentacyclo[7.5.0.02,8.04,12.05,11]tetradecane-7,14-dione 21678-37-5 AR-1D3324 (CAS 21678-37-5)
- Methyl (R)-3-amino-5-methylhexanoate (CAS 136703-73-6)
- N-(6,7-Dihydro-5H-[1,2,4]triazolo[3,4-b][1,3]thiazin-3-yl)-2-(thiophen-2-yl)acetamide (CAS 1030105-23-7)
- 6-(4-Benzylpiperazin-1-yl)nicotinaldehyde (CAS 886360-69-6)
- 2-Nitrophenyl β-D-fucopyranoside (CAS 1154-94-5)
- 2-Iodo-4-methoxypyridine (CAS 89640-54-0)
- Semaglutide Impurity 144 (CAS 394210-59-4)
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