Roxatidine Impurity 48 CAS 4530-45-4
| CAS No. | 4530-45-4 |
| Molecular Formula | C9H8Cl2O2 |
| Molecular Weight | 219.06 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Roxatidine Impurity 48 (CAS 4530-45-4) is a certified pharmaceutical impurity reference standard with the molecular formula C9H8Cl2O2 and a molecular weight of 219.06 g/mol.
Structurally, Roxatidine Impurity 48 (C9H8Cl2O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 219.06 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C9H8Cl2O2 |
| Molecular Weight | 219.06 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
Related Roxatidine Standards
- Roxatidine Impurity 34 (CAS 15504-60-6)
- Roxatidine Impurity 61 (CAS 83948-53-2)
- Roxatidine Impurity 80 (CAS 853574-98-8)
- Roxatidine Impurity 4 (CAS 73279-04-6)
- Roxatidine Impurity 45 (CAS 73152-41-7)
- Roxatidine Impurity 46 (CAS 4764-13-0)
- Roxatidine Impurity 71 (CAS CATO-C4X-121371)
- Roxatidine Impurity 58 (CAS 115062-97-0)
Recommended Standards
- 5,6-bis(chloromethyl)benzo[d][1,3]dioxole (CAS 23473-54-3)
- 2,4-Dichlorobenzyl Alcohol EP Impurity D (CAS 5468-96-2)
- 3-(4-Chlorophenoxy)propanoyl chloride 4878-06-2 (CAS 4878-06-2)
- Guanfacine Hydrochloride Impurity 1 (CAS 54551-83-6)
- Flupentixol Impurity 6 (E and Z Mixture) (CAS CATO-C4X-18956)
- Progesterone Impurity 65 (CAS CATO-C4X-150265)
- Venlafaxine EP Impurity F (CAS 93413-57-1)
- 3-amino-5,5-dimethylhexanoic acid hydrochloride (CAS 158414-70-1)
- 1-(3,4-Dimethylphenyl)-5-methyl-N-(4-methylphenyl)-1H-1,2,3-triazole-4-carboxamide (CAS 866872-27-7)
- Ethyl 2,4-dichloro-5-fluorobenzoate (CAS 103318-75-8)
- Poly(oxy-1,2-ethanediyl), .alpha.-sulfo-.omega.-(nonylphenoxy)-, sodium salt (1:1) (CAS 9014-90-8)
- (R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-3-carboxylic acid (CAS 193693-67-3)
- n-(4-Bromo-3-methylphenyl)-2,5-dimethylfuran-3-carboxamide (CAS 1016847-22-5)
- C-Peptide 2 (rat) (CAS 41594-08-5)
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