Isosorbide Dinitrate Impurity 15 CAS 551-43-9
| CAS No. | 551-43-9 |
| Molecular Formula | C6H8N2O8 |
| Molecular Weight | 236.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Isosorbide Dinitrate Impurity 15 is closely related to a carbohydrate-derived structure, an amide group in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Isosorbide Dinitrate Impurity 15 (CAS 551-43-9), a pharmacopoeial impurity reference standard (molecular formula C6H8N2O8, MW 236.14 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Isosorbide Dinitrate Impurity 15 (C6H8N2O8) is characterized by a carbohydrate-derived structure, an amide group. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H8N2O8 |
| Molecular Weight | 236.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 2 |
Related Isosorbide Standards
- Isosorbide Dinitrate Impurity 27 (CAS 575-86-0)
- Isosorbide Dinitrate (CAS 87-33-2)
- Isosorbide Dinitrate Impurity 26 (CAS CATO-C4X-223826)
- Isosorbide Dinitrate Impurity 4 (CAS 39813-48-4)
- Isosorbide Dinitrate Impurity 8 (CAS 39698-15-2)
- Isosorbide Dinitrate Impurity 7 (CAS 13042-38-1)
- Isosorbide-13C6 Dinitrate (CAS 1246815-45-1)
- Isosorbide-13C6 DiNitrate (CAS 1391051-97-0)
Recommended Standards
- 2,6-bis(chloranyl)quinoline-3-carbaldehyde 2,6-dichloro-3-quinolinecarboxaldehyde 73568-41-9 A837859 (CAS 73568-41-9)
- Methyl (4,4,5,5,5-pentafluoropentyl) carbonate (CAS 1980086-58-5)
- Ethyl 5-trifluoroacetyl-2-furanoate (CAS 898787-41-2)
- 3-Nitro-4-(2,2,2-trifluoroethoxy)aniline (CAS 1000339-84-3)
- Carbidopa Impurity 36 (CAS 1026009-73-3)
- Olopatadine Impurity 40 HCl (CAS CATO-C4X-171840)
- Perindopril Impurity 71 (CAS CATO-C4X-125271)
- Pinaverium Bromide Impurity 47 HCl (CAS CATO-C4X-246747)
- (3',2-Difluorobiphenyl-4-yl)methanamine (CAS 1214336-07-8)
- 4'-Bromo-5-(5,5-dimethyl-1,3-dioxan-2-YL)valerophenone (CAS 898785-80-3)
- L-Serine, O-(1,1-dimethylethyl)-2-methyl- (CAS 114396-73-5)
- rel-(1R,2S)-1-Amino-1,2,3,4-tetrahydronaphthalen-2-ol (CAS 7480-36-6)
- (4-(1-Morpholinoethyl)phenyl)boronic acid hydrochloride (CAS 1704069-64-6)
- Semaglutide impurity 107 (CAS CATO-C4X-2226107)
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