Isosorbide Dinitrate Impurity 4 CAS 39813-48-4
| CAS No. | 39813-48-4 |
| Molecular Formula | C8H11NO7 |
| Molecular Weight | 233.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Isosorbide Dinitrate Impurity 4.
As a process- or degradation-related impurity, Isosorbide Dinitrate Impurity 4 (CAS 39813-48-4, C8H11NO7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Isosorbide Dinitrate Impurity 4 (C8H11NO7) contains a carbohydrate-derived structure, an amide group. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H11NO7 |
| Molecular Weight | 233.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Nitrogen Atoms | 1 |
Related Isosorbide Standards
- Isosorbide Dinitrate Impurity 26 (CAS CATO-C4X-223826)
- Isosorbide Dinitrate Impurity 8 (CAS 39698-15-2)
- Isosorbide Dinitrate Impurity 15 (CAS 551-43-9)
- Isosorbide Dinitrate Impurity 27 (CAS 575-86-0)
- Isosorbide Dinitrate (CAS 87-33-2)
- Isosorbide Dinitrate Impurity 7 (CAS 13042-38-1)
- Isosorbide-13C6 Dinitrate (CAS 1246815-45-1)
- Isosorbide-13C6 DiNitrate (CAS 1391051-97-0)
Recommended Standards
- Carglumic Acid Impurity 5 (CAS CATO-C4X-20795)
- Oxolinic acid (CAS 26893-27-6)
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- (3-(Trifluoromethyl)phenyl)alanine (CAS 1008969-97-8)
- Ceftizoxime Impurity 10 (CAS 57028-71-4)
- Minodronic Acid Impurity 16 (CAS CATO-C4X-124116)
- Glycyrrhizic Acid Impurity N1 (CAS 1477-44-7)
- N-Benzyl-3-methyl-3H-purin-6-amine (CAS 14671-24-0)
- Z-Hyp(tBu)-OH (CAS 85201-91-8)
- 5-Fluoro-1-((2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (CAS 112668-56-1)
- N-(3-aminopropyl)-2-(3-methoxyphenyl)acetamide hydrochloride (CAS 1445131-10-1)
- 3-Amino-3-phenyl-1-propanol (CAS 14593-04-5)
- 4-D-Ser-Ganirelix (CAS CATO-C4X-23736)
- Semaglutide impurity 43 (CAS CATO-C4X-222643)
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