Isosorbide Dinitrate Impurity 27 CAS 575-86-0
| CAS No. | 575-86-0 |
| Molecular Formula | C6H8N2O8 |
| Molecular Weight | 236.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Isosorbide Dinitrate Impurity 27 (C6H8N2O8) is characterized by a carbohydrate-derived structure, an amide group. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Isosorbide Dinitrate Impurity 27 (CAS 575-86-0), a pharmacopoeial impurity reference standard (molecular formula C6H8N2O8, MW 236.14 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H8N2O8 |
| Molecular Weight | 236.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 2 |
Related Isosorbide Standards
- Isosorbide Dinitrate Impurity 15 (CAS 551-43-9)
- Isosorbide Dinitrate (CAS 87-33-2)
- Isosorbide Dinitrate Impurity 26 (CAS CATO-C4X-223826)
- Isosorbide Dinitrate Impurity 4 (CAS 39813-48-4)
- Isosorbide Dinitrate Impurity 8 (CAS 39698-15-2)
- Isosorbide Dinitrate Impurity 7 (CAS 13042-38-1)
- Isosorbide-13C6 Dinitrate (CAS 1246815-45-1)
- Isosorbide-13C6 DiNitrate (CAS 1391051-97-0)
Recommended Standards
- 2,6-bis(chloranyl)quinoline-3-carbaldehyde 2,6-dichloro-3-quinolinecarboxaldehyde 73568-41-9 A837859 (CAS 73568-41-9)
- 3-Nitro-4-(2,2,2-trifluoroethoxy)aniline (CAS 1000339-84-3)
- Methyl (4,4,5,5,5-pentafluoropentyl) carbonate (CAS 1980086-58-5)
- 2-bromo-N-(butan-2-yl)-3-methylbutanamide (CAS 1016740-90-1)
- Eplerenone EP Impurity F(Sodium Salt) (CAS 579484-30-3 (free base))
- Perindopril Impurity 112 (CAS CATO-C4X-1252112)
- Velpatasvir Impurity 5 (CAS CATO-C4X-28945)
- 4-(1H-pyrazol-1-yl)benzenesulfonamide (CAS 51891-85-1)
- Rel-(2R,3R)-2-(1,5-dimethyl-1H-pyrazol-4-yl)tetrahydrofuran-3-carboxylic acid (CAS 1807912-22-6)
- tert-Butyl ((6-(4-methylpiperazin-1-yl)pyridin-3-yl)methyl)carbamate (CAS 1355222-43-3)
- 3-Bromo-1,5-naphthyridin-4-amine (CAS 91477-46-2)
- N’-(pyridin-3-yl)benzenecarboximidamide (CAS 19673-11-1)
- 3-Methyl-N-(1-(pyridin-4-yl)ethyl)butan-2-amine (CAS 1042573-25-0)
- Semaglutide impurity 49 (CAS CATO-C4X-222649)
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