Fluticasone Impurity N6 CAS 572880-17-2
| CAS No. | 572880-17-2 |
| Molecular Formula | C27H29F3O7 |
| Molecular Weight | 522.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Fluticasone Impurity N6 (CAS 572880-17-2, C27H29F3O7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Fluticasone Impurity N6 (C27H29F3O7) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 522.51 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Fluticasone Impurity N6 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H29F3O7 |
| Molecular Weight | 522.51 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F-containing |
Related Fluticasone Standards
- Fluticasone Impurity 113 (CAS CATO-C4X-1650113)
- Fluticasone Impurity 105 (CAS CATO-C4X-1650105)
- Fluticasone Furoate EP Impurity E (CAS 398454-97-2)
- Fluticasone Impurity 48 (CAS 397864-58-3)
- Fluticasone Furoate Impurity 1 (CAS CATO-C4X-32541)
- Fluticasone Propionate EP Impurity K (CAS CATO-C4X-165044)
- Fluticasone Propionate Chloro Analog (CAS 80486-69-7)
- Fluticasone Impurity 99 (CAS 948566-13-0)
Recommended Standards
- Wybutosine (CAS 55196-46-8)
- 1,3-Bis(5-([2,2'-bipyridin]-6-yl)-1,3,4-oxadiazol-2-yl)benzene (CAS 866117-19-3)
- 3-(2-Chlorobenzyl)-6,8-diiodoquinazolin-4(3H)-one (CAS 302913-49-1)
- 3-[(4-Methyl-5-{2-[3-methyl-5-(trifluoromethyl)-1H-pyrazol-1-yl]-1,3-thiazol-4-yl}-4H-1,2,4-triazol-3-yl)sulfanyl]-4-oxo-4-phenylbutanoic acid (CAS 956357-63-4)
- Isavuconazole Impurity 33 (CAS 1180002-01-0)
- Tunodafil Impurity 13 (CAS CATO-C4X-311013)
- Crizotinib Impurity 50 (CAS CATO-C4X-102550)
- 2-(2-Isopropyl-5-methylphenoxy)aniline (CAS 946682-17-3)
- 3-butylfuran-2-carboxylic acid (CAS 2024437-55-4)
- 6-Nitrobenzo[b]thiophen-3-amine (CAS 1594760-95-8)
- Bromchlorbuterol Hydrochloride (CAS 78982-84-0)
- 1-(2-Bromoethoxy)-2,4-dimethylbenzene (CAS 18800-35-6)
- 2-(Ethoxymethylene)-4-ethylcyclohexan-1-one (CAS 1344832-29-6)
- Glu17-Semaglutide (CAS CATO-C4X-2226209)
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