Fluticasone Impurity 48 CAS 397864-58-3
| CAS No. | 397864-58-3 |
| Molecular Formula | C27H30F2O6S |
| Molecular Weight | 520.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Fluticasone Impurity 48 (C27H30F2O6S) is characterized by a steroid core, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Fluticasone Impurity 48 (CAS 397864-58-3), a pharmacopoeial impurity reference standard (molecular formula C27H30F2O6S, MW 520.59 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Fluticasone Impurity 48 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C27H30F2O6S |
| Molecular Weight | 520.59 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Fluticasone Standards
- Fluticasone Furoate EP Impurity E (CAS 398454-97-2)
- Fluticasone Impurity N6 (CAS 572880-17-2)
- Fluticasone Impurity 113 (CAS CATO-C4X-1650113)
- Fluticasone Impurity 105 (CAS CATO-C4X-1650105)
- Fluticasone Propionate EP Impurity K (CAS CATO-C4X-165044)
- Fluticasone Propionate Chloro Analog (CAS 80486-69-7)
- Fluticasone Impurity 99 (CAS 948566-13-0)
- Fluticasone Impurity 64 (CAS CATO-C4X-165064)
Recommended Standards
- BYS10 (CAS CATO-C4X-30232)
- 4-(4-Allyl-5-((4-phenoxybutyl)thio)-4H-1,2,4-triazol-3-yl)-2-(3-methyl-5-(trifluoromethyl)-1H-pyrazol-1-yl)thiazole (CAS 956200-81-0)
- PF-04217329 (CAS 1005549-94-9)
- (4AR,6S,7R,8S,8aS)-6-(ethylthio)-2-phenylhexahydropyrano[3,2-d][1,3]dioxine-7,8-diyl dibenzoate (CAS 56119-30-3)
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- 2'-Amino-3'-chloro-[1,1'-biphenyl]-2-ol (CAS 1424386-23-1)
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- 2-[2-[1-[1-[(1,1-Dimethylethoxy)carbonyl]-4-piperidinyl]-3-azetidinyl]ethynyl]-5-pyrimidinecarboxylic acid (CAS 2762066-50-0)
- [6-(morpholin-4-yl)pyridin-3-yl]methanamine dihydrochloride (CAS 1211358-60-9)
- 2-(5-methylfuran-2-yl)-2-(pyrrolidin-1-yl)ethan-1-amine (CAS 954577-56-1)
- 2-Amino-5-bromo-3-pyridinemethanol (CAS 335031-01-1)
- Des-Ile12-Aib13-Tirzepatide (CAS CATO-CPTD788960)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com