Indobufen Impurity 52 CAS 57960-84-6
| CAS No. | 57960-84-6 |
| Molecular Formula | C12H17NO2 |
| Molecular Weight | 207.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Indobufen Impurity 52 (CAS 57960-84-6, C12H17NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Indobufen Impurity 52 (C12H17NO2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Indobufen Impurity 52 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H17NO2 |
| Molecular Weight | 207.27 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Nitrogen Atoms | 1 |
Related Indobufen Standards
- Indobufen Impurity 45 (CAS CATO-C4X-179245)
- Indobufen Impurity 46 (CAS CATO-C4X-179246)
- Indobufen Impurity 74 (CAS CATO-C4X-179274)
- Indobufen Impurity 87 (CAS CATO-C4X-179287)
- Indobufen Impurity 39 (CAS 13048-83-4)
- Indobufen Impurity 73 (CAS CATO-C4X-179273)
- Indobufen Impurity 85 (CAS CATO-C4X-179285)
- Indobufen Impurity N9 (CAS 858006-96-9)
Recommended Standards
- Lacosamide Impurity 43 (CAS 69805-82-9)
- Terbutaline Impurity 44 (CAS 2095852-55-2)
- Etomidate Impurity 24 (CAS CATO-C4X-188424)
- Salbutamol Impurity 177 (CAS CATO-C4X-1176177)
- Ticarcillin EP Impurity A (CAS CATO-C4X-17631)
- Tegoprazan impurity 38 (CAS CATO-C4X-229738)
- Calcipotriol Impurity 11 (CAS 112849-17-9)
- (5-Fluoro-2-methyl-3-nitrophenyl)methanamine (CAS 1378530-58-5)
- 4-[2-(4-oxo-1,3-thiazolidin-3-yl)acetamido]benzoic acid (CAS 1099142-27-4)
- 2,4-Diamino-6-((4-iodophenyl)amino)pyrimidine-5-carboxamide (CAS 7254-18-4)
- N-(tert-butoxycarbonyl)-N-ethyl-L-phenylalanine (CAS 70961-24-9)
- tert-Butyl ((2-methyl-6-(piperazin-1-yl)pyridin-3-yl)methyl)carbamate (CAS 1355173-81-7)
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- D-Ser12-Semaglutide (CAS CATO-C4X-2226240)
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