Lifitegrast Impurity N4 CAS 58123-77-6
| CAS No. | 58123-77-6 |
| Molecular Formula | C7H5IO3 |
| Molecular Weight | 264.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Lifitegrast Impurity N4 (C7H5IO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, iodine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 264.02 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Lifitegrast Impurity N4 (CAS 58123-77-6, C7H5IO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Lifitegrast Impurity N4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H5IO3 |
| Molecular Weight | 264.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | I-containing |
Related Lifitegrast Standards
- Lifitegrast Impurity 150 (CAS CATO-C4X-2409150)
- Lifitegrast Impurity 151 (CAS CATO-C4X-2409151)
- Lifitegrast Impurity 72 (CAS 1956318-46-9)
- Lifitegrast Impurity 61 (CAS CATO-C4X-240961)
- Lifitegrast Impurity 120 (CAS CATO-C4X-2409120)
- Lifitegrast Impurity 113 (CAS CATO-C4X-2409113)
- Lifitegrast Impurity 167 (CAS CATO-C4X-2409167)
- Lifitegrast Impurity 161 (CAS CATO-C4X-2409161)
Recommended Standards
- 3-Hydroxy-2-iodobenzoic acid (CAS 75821-44-2)
- 3-Hydroxy-5-iodobenzoic acid (CAS 50765-21-4)
- 3,6-Dihydroxy-2-iodobenzaldehyde (CAS 70738-05-5)
- 3-Iodo-2-methyl-5-nitropyridine (CAS 911434-20-3)
- Crizotinib impurity 31 (CAS CATO-C4X-102531)
- Dorzolamide Impurity 17 (CAS CATO-C4X-122817)
- Ritonavir Impurity 57 (CAS CATO-C4X-175157)
- Fluorescent NIR 885 (CAS 177194-56-8)
- 1-(5-Ethoxyoxazol-2-yl)ethanone (CAS 175692-71-4)
- Tert-butyl (3S)-3-amino-4-(trifluoromethyl)piperidine-1-carboxylate (CAS 2166381-92-4)
- 5-(2,5-Dimethoxyphenyl)isoxazole-3-carboxylic Acid (CAS 953752-64-2)
- 1-(4-Methyl-1h-pyrazol-1-yl)acetone (CAS 1170037-69-0)
- 3-(4-Nitrophenoxy)pyrrolidine (CAS 1187930-72-8)
- Semaglutide impurity 62 (CAS CATO-C4X-222662)
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