Lifitegrast Impurity 167 CAS CATO-C4X-2409167
| CAS No. | CATO-C4X-2409167 |
| Molecular Formula | C13H16O3Si |
| Molecular Weight | 248.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Lifitegrast Impurity 167 (CAS CATO-C4X-2409167) is a certified pharmaceutical impurity reference standard with the molecular formula C13H16O3Si and a molecular weight of 248.35 g/mol.
The molecular framework of Lifitegrast Impurity 167 (C13H16O3Si) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C13H16O3Si |
| Molecular Weight | 248.35 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
Related Lifitegrast Standards
- Lifitegrast Impurity 161 (CAS CATO-C4X-2409161)
- Lifitegrast Impurity N99 (CAS 1195655-47-0)
- Lifitegrast Impurity N77 (CAS 1270132-45-0)
- Lifitegrast Impurity 116 (CAS CATO-C4X-2409116)
- Lifitegrast Impurity 96 (CAS 1270093-99-6)
- Lifitegrast Impurity 150 (CAS CATO-C4X-2409150)
- Lifitegrast Impurity 151 (CAS CATO-C4X-2409151)
- Lifitegrast Impurity 72 (CAS 1956318-46-9)
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