Lifitegrast Impurity 161 CAS CATO-C4X-2409161
| CAS No. | CATO-C4X-2409161 |
| Molecular Formula | C9H9BrClN |
| Molecular Weight | 246.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Lifitegrast Impurity 161 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine/bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Lifitegrast Impurity 161 (CAS CATO-C4X-2409161, C9H9BrClN) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Lifitegrast Impurity 161 (C9H9BrClN) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine/bromine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H9BrClN |
| Molecular Weight | 246.53 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 1 |
Related Lifitegrast Standards
- Lifitegrast Impurity 167 (CAS CATO-C4X-2409167)
- Lifitegrast Impurity N99 (CAS 1195655-47-0)
- Lifitegrast Impurity N77 (CAS 1270132-45-0)
- Lifitegrast Impurity 116 (CAS CATO-C4X-2409116)
- Lifitegrast Impurity 96 (CAS 1270093-99-6)
- Lifitegrast Impurity 27 (CAS 14046-52-7)
- Lifitegrast Impurity 150 (CAS CATO-C4X-2409150)
- Lifitegrast Impurity 151 (CAS CATO-C4X-2409151)
Recommended Standards
- 5-Bromo-7-chloro-2,3-dihydro-1H-inden-4-amine (CAS 2428479-12-1)
- 1,1,1,3,3,3-Hexaethyldisiloxane (CAS 994-49-0)
- 5-(3-Bromobut-3-en-1-yl)-2-chloropyridine (CAS 951886-60-5)
- 1,3-Di-tert-butyl-1,1,3,3-tetramethyldisiloxane (CAS 67875-55-2)
- Ivabradine Impurity 9 (CAS 1204612-29-2)
- Bilastine impurity 106 (CAS CATO-C4X-2253106)
- Bromhexine Impurity 26 (CAS CATO-C4X-106026)
- 2-(Bromomethyl)-6-methoxypyridine (CAS 156094-63-2)
- 3-Ethyl-6,7-dimethylquinoline-2-thiol (CAS 917746-30-6)
- 4-(2,6-Difluorophenyl)butanoic acid (CAS 899350-35-7)
- Rizatriptan impurity 17 (CAS CATO-C4X-175217)
- Oseltamivir Hydrochloride D3 (CAS 1093851-61-6(free base))
- 2-Bromo-N-(4-bromophenyl)-2,2-difluoroacetamide (CAS 1949728-30-6)
- Semaglutide Impurity 183 (CAS 159541-28-3)
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