Hydroxychloroquine Impurity 50 CAS 58175-87-4
| CAS No. | 58175-87-4 |
| Molecular Formula | C18H26ClN3 |
| Molecular Weight | 319.87 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Hydroxychloroquine Impurity 50 (CAS 58175-87-4, C18H26ClN3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Hydroxychloroquine Impurity 50 (C18H26ClN3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Hydroxychloroquine Impurity 50 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H26ClN3 |
| Molecular Weight | 319.87 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Hydroxychloroquine Standards
- Hydroxychloroquine Impurity 49 (CAS 58175-86-3)
- Hydroxychloroquine Impurity 88 (CAS CATO-C4X-183588)
- Hydroxychloroquine Impurity 73 (CAS CATO-C4X-183573)
- Hydroxychloroquine Impurity 3 (CAS 137433-25-1)
- Hydroxychloroquine EP Impurity C (CAS 4298-15-1)
- Hydroxychloroquine Impurity 90 (CAS CATO-C4X-183590)
- Hydroxychloroquine Impurity 41 (CAS 91828-61-4)
- Hydroxychloroquine Impurity 36 (CAS CATO-C4X-183536)
Recommended Standards
- Chloroquine (CAS 54-05-7)
- 5-Chloro-7-decylquinolin-8-ol (CAS 88559-42-6)
- 4-N-(5-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine (CAS 5428-61-5)
- 4-Chloro-N,N-dicyclohexylbenzamide (CAS 349089-31-2)
- Lenvatinib Impurity 98 (CAS CATO-C4X-114098)
- Nicergoline EP Impurity H (CAS 192504-81-7)
- Argatroban Impurity 46 (CAS 57876-69-4)
- 5-Chloro-2-methylquinazoline (CAS 1357301-51-9)
- 1-((4-(bromomethyl)phenyl)sulfonyl)pyrrolidine (CAS 151258-20-7)
- 4-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)methyl)-7,8-dimethyl-2H-chromen-2-one (CAS 850900-73-1)
- (3-Chloropyridin-2-yl)(imino)(methyl)-l6-sulfanone (CAS 2305254-72-0)
- 2-Methyl-2-(o-tolyl)propanal (CAS 127106-02-9)
- 2-({3-[(3-Phenylpropanoyl)amino]anilino}carbonyl)-benzoic acid (CAS 940459-88-1)
- Acetyl Hexapeptide-39 (CAS 1382088-38-1)
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