4-Amino-1-((2R,3S,4R,5R)-3-chloro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one CAS 58461-30-6
| CAS No. | 58461-30-6 |
| Molecular Formula | C9H12ClN3O4 |
| Molecular Weight | 261.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Amino-1-((2R,3S,4R,5R)-3-chloro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one.
4-Amino-1-((2R,3S,4R,5R)-3-chloro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (CAS 58461-30-6) is a high-purity analytical reference standard with the molecular formula C9H12ClN3O4 and a molecular weight of 261.66 g/mol.
The molecular framework of 4-Amino-1-((2R,3S,4R,5R)-3-chloro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (C9H12ClN3O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H12ClN3O4 |
| Molecular Weight | 261.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Amino Standards
- 4-Amino-5-chloro-1-((2R,6R)-6-(hydroxymethyl)-1,4-dioxan-2-yl)pyrimidin-2(1H)-one (CAS 132062-65-8)
- 4-Amino-2-(6-chlorooxazolo[5,4-b]pyridin-2-yl)phenol (CAS 1354751-03-3)
- 7-Amino-2-(4-chlorophenyl)[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one (CAS 1354764-81-0)
- 5-Amino-1-(2-chlorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (CAS 1416345-60-2)
- 7-Amino-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one (CAS 1881330-63-7)
- 2-amino-8-(3-chlorophenyl)-6,9-dihydro-1H-purin-6-one (CAS 857524-98-2)
- 3-[(1Z)-2-Amino-1,2-dicyanoeth-1-en-1-yl]-1-(4-chlorophenyl)urea (CAS 865658-74-8)
- 3-Amino-5-(4-chlorophenyl)-1,5-dihydro-6H-pyrazolo[4,3-c]pyridazin-6-one (CAS 338405-68-8)
Recommended Standards
- 4-(2-Chlorophenoxy)-3-methylisoxazolo[5,4-d]pyrimidine (CAS 672925-28-9)
- 4-Chloro-1-(3-methoxyphenyl)-6-oxo-1,6-dihydropyridazine-3-carbonitrile (CAS 306976-54-5)
- 3-Fluoro-4-(oxazol-2-yl)benzenesulfonyl chloride (CAS 2414108-77-1)
- 4-Chloro-1-(4-methoxyphenyl)-6-oxo-1,6-dihydropyridazine-3-carbonitrile (CAS 338395-88-3)
- N,N,3-Trimethylbenzamide (CAS 6935-65-5)
- 3-Hydroxy-8,9-methylenedioxypterocarpene (CAS 59901-98-3)
- 1,3,5-Trimethyl-1H-pyrazole-4-sulfonyl chloride (CAS 59340-27-1)
- Linoleic acid diethanolamide (CAS 56863-02-6)
- 4-(4-Bromothiophen-2-yl)butan-2-ol (CAS 1307015-89-9)
- Lansoprazole Impurity 27 (CAS CATO-C4X-111327)
- Pazopanib Impurity 14 (CAS CATO-C4X-172514)
- 3-Chloro-4,5-difluoropyridine (CAS 851178-98-8)
- 2-(4-Methoxyphenyl)-1H-pyrrole-3-carbaldehyde (CAS 90180-46-4)
- Cholecystokinin Octapeptide (sulfated) (H-2060.0005) (CAS 25679-23-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com