Glycopyrronium Bromide EP Impurity N Bromide CAS 58493-54-2
| CAS No. | 58493-54-2 |
| Molecular Formula | C19H28NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Glycopyrronium Bromide EP Impurity N Bromide is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Glycopyrronium Bromide EP Impurity N Bromide (CAS 58493-54-2) is a certified pharmaceutical impurity reference standard with the molecular formula C19H28NO3Br and a molecular weight of 398.34 g/mol.
The molecular framework of Glycopyrronium Bromide EP Impurity N Bromide (C19H28NO3Br) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Glycopyrronium Bromide EP Impurity N Bromide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H28NO3 Br |
| Molecular Weight | 398.34 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Glycopyrronium Standards
- Glycopyrronium Bromide EP Impurity G (CAS 13118-10-0)
- Glycopyrronium Bromide EP Impurity G (CAS 13118-11-1)
- Glycopyrronium Bromide Impurity N1 (CAS 13283-82-4)
- Glycopyrronium Bromide impurity 15 (CAS 1404453-67-3)
- Glycopyrronium Bromide Impurity 7 (CAS 1404453-68-4)
- Glycopyrronium Bromide EP Impurity H (CAS 15206-55-0)
- Glycopyrronium Bromide impurity 16 (CAS 16098-80-9)
- Glycopyrronium Tosylate (CAS 1624259-25-1)
Recommended Standards
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- 4-(Bromomethyl)-1-(methylsulfonyl)-2-(trifluoromethyl)benzene (CAS 942199-45-3)
- 1-(3-Hydroxy-5-iodo-1H-indol-1-yl)ethanone (CAS 26490-99-3)
- 2-Chloro-3-(4-(indoline-1-carbonyl)piperidin-1-yl)naphthalene-1,4-dione (CAS 685106-73-4)
- 1-Phenylanthracene (CAS 1714-09-6)
- 2-Hydroxyethyl-N-Octyl-Sulfide (CAS 3547-33-9)
- Semaglutide impurity 26 (CAS CATO-C4X-222626)
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