1-Chloromethyl-3-methanesulfonylbenzene CAS 586373-70-8
| CAS No. | 586373-70-8 |
| Molecular Formula | C8H9ClO2S |
| Molecular Weight | 204.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
1-Chloromethyl-3-methanesulfonylbenzene (CAS 586373-70-8), molecular formula C8H9ClO2S and molecular weight 204.67 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, 1-Chloromethyl-3-methanesulfonylbenzene is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 204.67 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H9ClO2S |
| Molecular Weight | 204.67 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Chloromethyl Standards
- 4-(Chloromethyl)-2-(thiophen-3-yl)-1,3-dioxolane (CAS 1556649-68-3)
- 1-(Chloromethyl)-2-methanesulfonylbenzene (CAS 168551-51-7)
- Ethyl 3-(chloromethyl)thiophene-2-carboxylate (CAS 1823887-17-7)
- 1-((Chloromethyl)sulfonyl)-4-methylbenzene (CAS 7569-26-8)
- 4-(chloromethyl)-2-(thiophen-2-yl)-1,3-dioxolane (CAS 93676-36-9)
- methyl 4-(chloromethyl)-5-methylthiophene-2-carboxylate (CAS 28686-93-3)
- 6-(Chloromethyl)-2,3'-bipyridine (CAS 1227508-91-9)
- 4-(Chloromethyl)-2,3'-bipyridine (CAS 1227586-43-7)
Recommended Standards
- 1-Chloro-4-(ethylsulfonyl)benzene (CAS 7205-80-3)
- 1-Phenylethane-1-sulfonyl chloride (CAS 58032-85-2)
- 1-Chloro-3-ethanesulfonylbenzene (CAS 494870-50-7)
- 2-(3-Chlorothiophen-2-yl)-2-methylpropanoic acid (CAS 950604-74-7)
- 6-(((4-Methylthiazol-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 2-ethylbutanoate (CAS 896302-00-4)
- Methyl 4-(5-hydroxypyridin-3-yl)benzoate (CAS 1258612-64-4)
- (S)-2-((tert-butoxycarbonyl)amino)-3-(quinolin-4-yl)propanoic acid (CAS 2015385-62-1)
- ethyl 7-chloro-2-methyl-thiazolo[5,4-b]pyridine-6-carboxylate (CAS 2178986-14-4)
- 4-(1H-pyrrol-1-yl)pyridin-2-amine (CAS 1314354-37-4)
- (5-((5-Fluoro-2-methylphenyl)sulfonyl)-1-methyl-3-phenyl-1H-pyrazol-4-yl)methyl 3,4-dichlorobenzoate (CAS 956262-86-5)
- 3-Amino-4-morpholinotetrahydrothiophene 1,1-dioxide (CAS 1052614-40-0)
- Methyl (2S,4S)-4-[2-(tert-butyl)-4-chlorophenoxy]-2-pyrrolidinecarboxylate hydrochloride (CAS 1354485-76-9)
- 4-Ethoxy-3-(trifluoromethyl)benzenesulfonyl chloride (CAS 1706446-86-7)
- Serpent Peptide (CAS 823202-99-9)
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