Levodopa EP Impurity C-d3 (S-isomer) (L-3-O-Methyldopa-d3) CAS 586954-09-8

Purity >80%In StockPharmacopoeial Impurity Standards
CAS No.586954-09-8
Molecular Formula-
Molecular Weight214.23 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Levodopa EP Impurity C-d3 (S-isomer) (L-3-O-Methyldopa-d3) CAS 586954-09-8 chemical structure

Description

The occurrence of Levodopa EP Impurity C-d3 (S-isomer) (L-3-O-Methyldopa-d3) is closely related to deuterium isotope labeling, an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

As a process- or degradation-related impurity, Levodopa EP Impurity C-d3 (S-isomer) (L-3-O-Methyldopa-d3) (CAS 586954-09-8, C10H10D3NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

Structurally, Levodopa EP Impurity C-d3 (S-isomer) (L-3-O-Methyldopa-d3) (C10H10D3NO4) contains deuterium isotope labeling, an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 6.5, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 214.23 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC10H10D3NO4
Molecular Weight214.23 g/mol
AppearanceOff-white to pale yellow crystalline powder. (faint amine-like odor)
Purity>80%
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in methanol, ethanol, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening
Degree of Unsaturation (DBE)6.5
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1984
Nitrogen Atoms1

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