Levodopa EP Impurity A CAS 27244-64-0
| CAS No. | 27244-64-0 |
| Molecular Formula | C9H11NO5 |
| Molecular Weight | 213.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Levodopa EP Impurity A (CAS 27244-64-0) is a certified pharmaceutical impurity reference standard with the molecular formula C9H11NO5 and a molecular weight of 213.19 g/mol.
The molecular framework of Levodopa EP Impurity A (C9H11NO5) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H11NO5 |
| Molecular Weight | 213.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Nitrogen Atoms | 1 |
Related Levodopa Standards
- Rac-Levodopa EP Impurity A (CAS 21373-30-8)
- Levodopa EP Impurity C-d3 (S-isomer) (L-3-O-Methyldopa-d3) (CAS 586954-09-8)
- Levodopa EP Impurity C (CAS 7636-26-2)
- Levodopa EP Impurity C (CAS 15402-76-3)
- Levodopa EP Impurity C (S-Isomer) (CAS 300-48-1)
- Levodopa Impurity 23 (CAS 75290-51-6)
- Levodopa Impurity 8 (CAS 64192-68-3)
- Levodopa Impurity N2 (CAS 55-59-4)
Recommended Standards
- Droxidopa Impurity 4 (CAS CATO-C4X-16254)
- Pranoprofen Impurity 82 (CAS CATO-C4X-181182)
- Droxidopa Impurity 3 (CAS CATO-C4X-16253)
- Fruquintinib Impurity 2 (CAS 2357686-21-4)
- Indapamide Impurity 52 (CAS CATO-C4X-140052)
- Sitagliptin Impurity 16 (CAS 849832-73-1)
- Sodium Fusidate EP Impurity D (CAS CATO-C4X-11974)
- Ibrutinib Impurity 3 (CAS 1288338-96-4)
- Relugolix-d6 (CAS 737789-87-6 (non-labelled))
- N-(2-azidoethyl)-2-methylpropanamide (CAS 1251204-27-9)
- 3-Acetyl-2,4-hexanedione (CAS 17448-88-3)
- N-methyl-N,3-diphenylpropanamide (CAS 18859-20-6)
- Quinoxaline-2-sulfonamide (CAS 1247528-73-9)
- Myristoyl Pentapeptide-4 (CAS 1392416-25-9)
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