Levodopa Impurity 8 CAS 64192-68-3
| CAS No. | 64192-68-3 |
| Molecular Formula | C9H9NO5 |
| Molecular Weight | 211.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Levodopa Impurity 8 (C9H9NO5) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Levodopa Impurity 8 (CAS 64192-68-3, C9H9NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Levodopa Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H9NO5 |
| Molecular Weight | 211.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Nitrogen Atoms | 1 |
Related Levodopa Standards
- Levodopa EP Impurity C (CAS 7636-26-2)
- Levodopa EP Impurity C (CAS 15402-76-3)
- Levodopa EP Impurity C (S-Isomer) (CAS 300-48-1)
- Rac-Levodopa EP Impurity A (CAS 21373-30-8)
- Levodopa EP Impurity A (CAS 27244-64-0)
- Levodopa EP Impurity C-d3 (S-isomer) (L-3-O-Methyldopa-d3) (CAS 586954-09-8)
- Levodopa Impurity 23 (CAS 75290-51-6)
- Levodopa Impurity 22 (CAS 28900-64-3)
Recommended Standards
- Ethyl 6-amino-5-nitronicotinate (CAS 90765-07-4)
- Methyl 2-(2-hydroxy-3-nitrophenyl)acetate (CAS 866885-53-2)
- ethyl 3-hydroxy-2-nitrobenzoate (CAS 81914-58-1)
- Methyl 2-(2-nitrophenoxy)acetate (CAS 7506-93-6)
- Fluticasone Carbothioic Acid Impurity (CAS 80474-45-9)
- Posaconazole impurity 212 (CAS CATO-C4X-1208212)
- Cefdinir CP Impurity Q (CAS CATO-C4X-121055)
- Fexofenadine Impurity 40 (CAS 1390644-37-7)
- Methyl 5-amino-4-carbamoyl-1H-pyrazole-1-carboxylate (CAS 220131-61-3)
- 3-chloroprop-2-en-1-yl 2-hydroxypropanoate (CAS 64058-39-5)
- Macitentan Impurity 24 (CAS 556797-16-1)
- N-((4,5-dimethyloxazol-2-yl)methyl)thietan-3-amine (CAS 1863907-40-7)
- Dantrolene USP Related Compound A (CAS 301359-05-7)
- Peptide-GMF (CAS CATO-CPTD788469)
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