Phenacetin Impurity 9 CAS 588-52-3
| CAS No. | 588-52-3 |
| Molecular Formula | C16H18N2O2 |
| Molecular Weight | 270.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Phenacetin Impurity 9 (CAS 588-52-3) is a certified pharmaceutical impurity reference standard with the molecular formula C16H18N2O2 and a molecular weight of 270.33 g/mol.
The molecular framework of Phenacetin Impurity 9 (C16H18N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Phenacetin Impurity 9 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H18N2O2 |
| Molecular Weight | 270.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 2 |
Related Phenacetin Standards
- Phenacetin Impurity 12 (CAS 21650-66-8)
- Phenacetin Impurity 13 (CAS 71297-93-3)
- Phenacetin Impurity 2 (CAS 614-26-6)
- Phenacetin Impurity 8 (CAS 188905-67-1)
- Phenacetin Impurity N1 (CAS 21650-51-1)
- Phenacetin Impurity 16 (CAS 30926-04-6)
- Phenacetin Impurity 10 (CAS 15596-57-3)
- Phenacetin Impurity 7 (CAS 60457-49-0)
Recommended Standards
- N-Nitroso Diphenhydramine EP Impurity A (CAS 55855-43-1)
- N-Nitroso Pyridbenzamine hydrochloride (CAS 57830-36-1)
- Acetaminophen Impurity 24 (CAS 1991204-56-8)
- Antipyrine Impurity 3 (CAS 1430813-66-3)
- Isoprenaline Impurity 29 (CAS CATO-C4X-277529)
- Fenofibrate EP Impurity C (CAS 217636-47-0)
- Nebivolol Impurity 40 (CAS CATO-C4X-196840)
- Methyl 2,4-dibromo-6-(difluoromethoxy)phenylacetate (CAS 1806348-83-3)
- Bempedoic Acid Impurity 47 (CAS CATO-C4X-218947)
- 1-Propanaminium, N,N,N-trimethyl-3-[(2-methyl-1-oxo-2-propenyl)amino]-, chloride, homopolymer (CAS 68039-13-4)
- 1,1-Dimethylethyl 3-amino-1H-pyrazole-4-carboxylate (CAS 1646543-44-3)
- Ethyl 2-[(2-methylphenyl)carbamoyl]acetate (CAS 104330-53-2)
- 1-(3-Bromo-2,2-dimethylpropyl)-2-fluorobenzene (CAS 1482171-77-6)
- Insulin Degludec Impurity 26 (CAS CATO-C4X-215726)
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