Iloperidone Impurity 11 CAS 59084-16-1
| CAS No. | 59084-16-1 |
| Molecular Formula | C8H12ClNO2 |
| Molecular Weight | 189.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 189.64 g/mol gives Iloperidone Impurity 11 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Iloperidone Impurity 11 (CAS 59084-16-1) is a certified pharmaceutical impurity reference standard with the molecular formula C8H12ClNO2 and a molecular weight of 189.64 g/mol.
Iloperidone Impurity 11 (C8H12ClNO2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H12ClNO2 |
| Molecular Weight | 189.64 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Iloperidone Standards
- Iloperidone Impurity 31 (CAS 116218-80-5)
- Iloperidone Impurity 19 (CAS 54771-60-7)
- Iloperidone Impurity 8 (CAS 1209459-88-0)
- Iloperidone Impurity 3 (CAS 792857-93-3)
- Iloperidone Impurity 1 (CAS 207298-39-3)
- Iloperidone Stage -I Impurity (CAS 58113-30-7)
- Iloperidone Impurity 6 (CAS 3245-49-6)
- Iloperidone Impurity 15 (CAS 81055-36-9)
Recommended Standards
- 706-07-0 Benzene, 1-chloro-4-(2-nitroethenyl)- (9CI) Styrene, p-chloro-beta-nitro- 3-05-00-01181 (Beilstein Handbook Reference) BRN 2208373 p-Chloro-beta-nitro-styrene 4-Chloro-beta-nitrostyrene p-Cloro-beta-nitrostirene [Italian] NSC 2547 p-Cloro-beta-nitrostirene (CAS 706-07-0)
- 2-(1-azidoethyl)-3-chloro-pyrazine (CAS 440672-65-1)
- (E)-1-chloro-3-(2-nitrovinyl)benzene 37888-03-2 Trans-1-Chloro-3-(2-nitro-vinyl)-benzene (CAS 37888-03-2)
- 2-Butyl-d3-4-chloro-1H-imidazole-5-carboxaldehyde (CAS 1189927-81-8)
- Ketorolac Impurity 48 (CAS CATO-C4X-166948)
- Besifloxacin Impurity 4 (CAS CATO-C4X-10044)
- Amlodipine Impurity 81 (CAS CATO-C4X-109581)
- 4-Hydroxy-7-phenoxyisobenzofuran-1,3-dione (CAS 89450-88-4)
- 3-Amino-N-(4-bromo-phenyl)-benzenesulfonamide (CAS 380349-08-6)
- 2-(2,3-Dimethoxybenzylidene)-6-phenyl-2H-thiazolo[3,2-b][1,2,4]triazine-3,7-dione (CAS 463366-94-1)
- N-(1-(1-benzylpyrrolidin-3-yl)ethyl)thietan-3-amine (CAS 2008708-58-3)
- 5-(Ethylsulfonyl)furan-2-carboxylic acid (CAS 1280703-34-5)
- Ethyl Nicotinate-1,2,3,4,5,6- (CAS 1346604-87-2)
- Polyphemusin II-Derived Peptide (CAS 229030-20-0)
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