Iloperidone Impurity 6 CAS 3245-49-6
| CAS No. | 3245-49-6 |
| Molecular Formula | C12H15BrO3 |
| Molecular Weight | 287.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Iloperidone Impurity 6 (C12H15BrO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 287.15 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Iloperidone Impurity 6 (CAS 3245-49-6, C12H15BrO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Iloperidone Impurity 6 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H15BrO3 |
| Molecular Weight | 287.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Br-containing |
Related Iloperidone Standards
- Iloperidone Impurity 15 (CAS 81055-36-9)
- Iloperidone Stage -I Impurity (CAS 58113-30-7)
- Iloperidone Impurity 1 (CAS 207298-39-3)
- Iloperidone Impurity 3 (CAS 792857-93-3)
- Iloperidone Impurity 8 (CAS 1209459-88-0)
- Iloperidone Impurity 19 (CAS 54771-60-7)
- Iloperidone Impurity 31 (CAS 116218-80-5)
- Iloperidone Impurity 5 (CAS 19417-90-4)
Recommended Standards
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- 5-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidin-2-one (CAS 1004294-99-8)
- Palbociclib Impurity 181 (CAS 2601903-88-0)
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- 1-(3-Fluorophenyl)-3-phenylpropan-1-amine (CAS 1184565-41-0)
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