Eltrombopag Impurity 40 CAS 591-17-3
| CAS No. | 591-17-3 |
| Molecular Formula | C7H7Br |
| Molecular Weight | 171.03 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Eltrombopag Impurity 40 (CAS 591-17-3), a pharmacopoeial impurity reference standard (molecular formula C7H7Br, MW 171.03 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Eltrombopag Impurity 40 (C7H7Br) is characterized by bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H7Br |
| Molecular Weight | 171.03 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Br-containing |
Related Eltrombopag Standards
- Eltrombopag impurity 142 (CAS CATO-C4X-1198142)
- Eltrombopag Impurity 31 (CAS 25487-66-5)
- Eltrombopag Impurity 158 (CAS CATO-C4X-1198158)
- Eltrombopag impurity 145 (CAS 757889-55-7)
- Eltrombopag Impurity 68 (CAS 53442-24-3)
- Eltrombopag Impurity 35 (CAS 28165-50-6)
- Eltrombopag Impurity 102 (CAS 118048-94-5)
- Eltrombopag Impurity 119 (CAS CATO-C4X-1198119)
Recommended Standards
- N-Nitroso Cyclophosphamide EP Impurity C (CAS 67856-68-2)
- Benzyl Bromide (CAS 100-39-0)
- 4-Bromotoluene (CAS 106-38-7)
- 2-Bromotoluene (CAS 95-46-5)
- Revefenacin Impurity 23 (CAS CATO-C4X-203123)
- Etrasimod impurity 19 (CAS CATO-C4X-321419)
- Xanomeline impurity 52 (CAS CATO-C4X-330152)
- 3-Amino-4-Methyl Benzoly Chloride (CAS 805179-39-9)
- Methyl 6-(methylamino)hexanoate (CAS 62222-21-3)
- 4-(5-(4-(Dimethylamino)phenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid (CAS 394225-50-4)
- p-APMSF (hydrochloride) (CAS 74938-88-8)
- (S)-N-(2,5-Dioxotetrahydrofuran-3-yl)benzamide (CAS 54819-23-7)
- 3-Isopropylbenzoyl chloride (CAS 325770-58-9)
- Semaglutide impurity 50 (CAS 2773558-66-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com