Flumazenil Impurity 9 CAS 5973-29-5
| CAS No. | 5973-29-5 |
| Molecular Formula | C10H9ClN2O2 |
| Molecular Weight | 224.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Flumazenil Impurity 9 (C10H9ClN2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Flumazenil Impurity 9 (CAS 5973-29-5, C10H9ClN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Flumazenil Impurity 9 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H9ClN2O2 |
| Molecular Weight | 224.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Flumazenil Standards
- Flumazenil Impurity 22 (CAS 193693-31-1)
- Flumazenil Impurity 13 (CAS CATO-C4X-143213)
- Flumazenil Impurity 19 (CAS 548487-68-9)
- Flumazenil EP Impurity D (CAS 78755-80-3)
- Flumazenil Impurity 10 (CAS 162110-24-9)
- Flumazenil EP Impurity A (CAS 84378-44-9)
- Flumazenil Impurity 20 (CAS CATO-C4X-143220)
- Flumazenil EP Impurity E (CAS 78756-03-3)
Recommended Standards
- Gefitinib Impurity 78 (CAS CATO-C4X-111778)
- Tizanidine Impurity 65 (CAS 67357-54-4)
- Ganciclovir Impurity 24 (CAS 86761-37-7)
- Tizanidine Impurity 66 (CAS 67357-53-3)
- Minocycline EP Impurity G DiTFA salt (CAS 601455-95-2(free base))
- Upadacitinib Impurity 153 (CAS CATO-C4X-2405153)
- Pinaverium Bromide Impurity 11 (CAS 1970218-70-2)
- 2-[3-(2-Ethyl-4-oxo-3,4-dihydroquinazolin-3-yl)propyl]-2,3-dihydro-1H-isoindole-1,3-dione (CAS 866010-32-4)
- 1,2-Dibenzylhydrazine (CAS 7626-68-8)
- 2-Amino-1-(4-hydroxy-1-piperidinyl)-1-propanonehydrochloride (CAS 1236262-03-5)
- S-(4-Cyanobutyl)thioacetate (CAS 252949-42-1)
- 2-{[3-Oxo-2-benzofuran-1(3H)-yliden]methyl}-1-hydrazinecarbothioamide (CAS 320424-97-3)
- Dalbavancin Impurity 18 (CAS CATO-C4X-160218)
- Insulin Degludec Impurity 3 (CAS CATO-C4X-21573)
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