Tizanidine Impurity 65 CAS 67357-54-4
| CAS No. | 67357-54-4 |
| Molecular Formula | C10H9ClN2O2 |
| Molecular Weight | 224.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 224.64 g/mol gives Tizanidine Impurity 65 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Tizanidine Impurity 65 (CAS 67357-54-4, C10H9ClN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Tizanidine Impurity 65 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 224.64 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H9ClN2O2 |
| Molecular Weight | 224.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Tizanidine Standards
- Tizanidine Impurity 66 (CAS 67357-53-3)
- Tizanidine Impurity 67 (CAS 67357-56-6)
- Tizanidine Guanidine Impurity (CAS 125292-37-7)
- Tizanidine EP Impurity A (CAS 51322-69-1)
- Tizanidine impurity 29 (CAS CATO-C4X-144529)
- Tizanidine impurity 20 (CAS CATO-C4X-144520)
- Tizanidine impurity 26 (CAS CATO-C4X-144526)
- Tizanidine Hydrochloride EP Impurity G (CAS 51322-80-6)
Recommended Standards
- Flumazenil Impurity 9 (CAS 5973-29-5)
- Gefitinib Impurity 78 (CAS CATO-C4X-111778)
- Ganciclovir Impurity 24 (CAS 86761-37-7)
- Bosutinib Impurity N1 (CAS 879644-03-8)
- Moxifloxacin impurity N1 (CAS 147459-51-6)
- Ibuprofen Impurity 106 (CAS CATO-C4X-1082106)
- Tegoprazan Impurity 6 (CAS CATO-C4X-22976)
- Allyl 2-phenylcyclopropanecarboxylate (CAS 94727-95-4)
- 2-(Pyridin-2-yl)-5,6,7,8-tetrahydro-4H-oxazolo[4,5-c]azepine (CAS 1246892-67-0)
- (2-Methyl-benzyl)-(3-pentafluoroethyloxy-propyl)-amine (CAS 1208080-82-3)
- N-(Benzo[c][1,2,5]thiadiazol-4-yl)-2-oxo-2H-pyran-5-carboxamide (CAS 1207005-81-9)
- 1-(oxan-4-yl)azetidine-3-carboxylic acid (CAS 1127402-33-8)
- Pyrazolo[1,5-a]pyridin-4-ylmethanamine (CAS 1554583-09-3)
- Semaglutide impurity 38 (CAS CATO-C4X-222638)
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