Gentamicin Impurity 8 CAS 59751-72-3
| CAS No. | 59751-72-3 |
| Molecular Formula | C20H41N5O7 |
| Molecular Weight | 463.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Gentamicin Impurity 8 is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Gentamicin Impurity 8 (CAS 59751-72-3, C20H41N5O7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Gentamicin Impurity 8 (C20H41N5O7) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H41N5O7 |
| Molecular Weight | 463.57 g/mol |
| Appearance | White to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1974 |
| Nitrogen Atoms | 5 |
Related Gentamicin Standards
Recommended Standards
- rel-N-(5-(3,5-Dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3R,5S)-3,5-dimethylpiperazin-1-yl)benzamide (CAS 1035270-39-3)
- UNC2881 (CAS 1493764-08-1)
- Valsartan Impurity 9 (CAS 1111177-30-0)
- 2-(3-(2,5-Dimethyl-1H-pyrrol-1-yl)thiophen-2-yl)-6-tosylpyrazolo[1,5-a]pyrimidin-7-amine (CAS 439108-96-0)
- Cloxacillin Impurity N1 (CAS 4357-94-2)
- Butylhydroxyanisole Impurity 3 (CAS CATO-C4X-15703)
- Belumosudil Impurity N7 (CAS 911419-33-5)
- Methyl 3-(N',N'-dimethylhydrazinecarbonyl)propanoate (CAS 28402-64-4)
- 2,6-Dimethylterephthalic acid (CAS 80238-12-6)
- 2-Chloro-5-cyclopropoxy-N,N-dimethylpyridin-3-amine (CAS 1243317-35-2)
- 3-Bromo-4-(2,2-difluoroacetamido)benzene-1-sulfonyl chloride (CAS 1695744-02-5)
- 2-Oxo-1,2,3,4-tetrahydroquinoline-5-carbaldehyde (CAS 72394-52-6)
- 2-Amino-3-bromomethyl-4-(trifluoromethyl)pyridine (CAS 1227595-23-4)
- Peptide 6A (H-6905.0005) (CAS 73549-32-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com