Cloxacillin Impurity N1 CAS 4357-94-2
| CAS No. | 4357-94-2 |
| Molecular Formula | C12H10ClNO3 |
| Molecular Weight | 251.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Cloxacillin Impurity N1 (CAS 4357-94-2) is a certified pharmaceutical impurity reference standard with the molecular formula C12H10ClNO3 and a molecular weight of 251.67 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Cloxacillin Impurity N1 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 251.67 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Cloxacillin Impurity N1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H10ClNO3 |
| Molecular Weight | 251.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Cloxacillin Standards
- Cloxacillin Impurity 15 (CAS 1598387-74-6)
- Cloxacillin Impurity 17 (CAS 91059-01-7)
- Cloxacillin Impurity 18 (CAS 25629-50-9)
- Cloxacillin Impurity 26 (CAS CATO-C4X-159726)
- Cloxacillin Sodium Impurity 6 (CAS 83817-50-9)
- Cloxacillin EP Impurity D (CAS 23598-72-3)
- Cloxacillin Impurity 23 (CAS CATO-C4X-159723)
- Cloxacillin Impurity 27 (CAS CATO-C4X-159727)
Recommended Standards
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- VH032 (CAS 1448188-62-2)
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- Semaglutide Impurity 5 (CAS 23406-82-8)
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