Acotiamide Impurity 40 CAS 5981-37-3
| CAS No. | 5981-37-3 |
| Molecular Formula | C8H8O5 |
| Molecular Weight | 184.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Acotiamide Impurity 40 (CAS 5981-37-3, C8H8O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Acotiamide Impurity 40 (C8H8O5) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8O5 |
| Molecular Weight | 184.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
Related Acotiamide Standards
- Acotiamide Impurity 26 (CAS 67370-98-3)
- Acotiamide Impurity 9 (CAS 948053-83-6)
- Acotiamide Hydrochloride Impurity 67 (CAS 5398-36-7)
- Acotiamide Impurity 32 (CAS 5653-53-2)
- Acotiamide Impurity 11 (CAS 5722-93-0)
- Acotiamide Impurity 37 (CAS 610-90-2)
- Acotiamide Impurity 21 (CAS 118452-04-3)
- Acotiamide Impurity 2 (CAS 490-64-2)
Recommended Standards
- Aquathol disodium (CAS 6385-60-0)
- 6-(Difluoromethyl)pyrazolo[1,5-a]pyrimidin-3-amine (CAS 2573213-87-1)
- Cyclobuta[b]quinoxaline-1,2-dione (CAS 64014-14-8)
- 5-Ethyl-4-nitro-1h-pyrazole-3-carboxamide (CAS 215298-73-0)
- Linezolid Impurity 63 (CAS 348626-43-7)
- Landiolol Impurity 6 (CAS CATO-C4X-26216)
- Pregabalin impurity 99 (CAS 1511511-44-6)
- 2-Aminoquinolin-5-ol (CAS 1261844-98-7)
- 2-Cyclopentyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 66217-55-8)
- 3-Ethyl 2-methyl 4-methyl-1H-pyrrole-2,3-dicarboxylate (CAS 67855-96-3)
- 3-((4-Chlorophenyl)sulfonyl)-N-(4-isopropylphenyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine (CAS 892738-90-8)
- (S)-3-(4-Acetylphenyl)-4-ethyloxazolidin-2-one (CAS 572923-18-3)
- 4-((3-Cyanophenyl)amino)-4-oxobutanoic acid (CAS 303770-25-4)
- Peptide 436 (CAS CATO-CPTD788436)
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