Pilocarpine EP Impurity A (HNO3) CAS 5984-94-1
| CAS No. | 5984-94-1 |
| Molecular Formula | C11H16N2O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Pilocarpine EP Impurity A (HNO3) (CAS 5984-94-1, C11H16N2O2:HNO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Pilocarpine EP Impurity A (HNO3) (C11H16N2O2:HNO3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Pilocarpine EP Impurity A (HNO3) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H16N2O2 : HNO3 |
| Molecular Weight | 271.27 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 3 |
Related Pilocarpine Standards
- Pilocarpine EP Impurity C Sodium Salt (CAS 101769-87-3)
- Pilocarpine-d3 HydrochlorideDiscontinued (CAS 1217838-88-4)
- Pilocarpine Nitrate (CAS 148-72-1)
- Pilocarpine Impurity 10 (CAS 2833-30-9)
- Pilocarpine Hydrochloride EP Impurity B (CAS 28406-15-7)
- Pilocarpine EP Impurity A HCl (CAS 28958-85-2)
- Pilocarpine Hydrochloride EP Impurity C (CAS 34350-99-7)
- Pilocarpine HCl (CAS 54-71-7)
Recommended Standards
- Droperidol Impurity 18 (CAS CATO-C4X-276918)
- Upadacitinib Impurity 9 (CAS CATO-C4X-24059)
- CAS CATO-C3D-262677 (CAS CATO-C3D-262677)
- Dimefline HCl (CAS 1165-48-6)
- Maytansinoid Impurity 14 (CAS CATO-C4X-22514)
- 2-(4-amino-1H-pyrazol-1-yl)propanoic acid,HCl (CAS 1431970-21-6)
- 6-Bromo-4-fluoro-1,2-dihydro-3H-indazol-3-one (CAS 887568-01-6)
- 4-Cyclopropoxy-5-methylpicolinamide (CAS 1243464-79-0)
- 6-Chloro-2,4,8-trimethylquinoline (CAS 105907-08-2)
- Peptide Impurity 40 (CAS CATO-CPTD788840)
Why CATO?
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