Selumetinib CAS 606143-52-6
| CAS No. | 606143-52-6 |
| Molecular Formula | C17H15BrClFN4O3 |
| Molecular Weight | 457.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Selumetinib (CAS 606143-52-6) is a high-purity analytical reference standard with the molecular formula C17H15BrClFN4O3 and a molecular weight of 457.68 g/mol.
Based on its molecular formula C17H15BrClFN4O3, Selumetinib contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 457.68 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Selumetinib meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H15BrClFN4O3 |
| Molecular Weight | 457.68 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl/Br-containing |
| Nitrogen Atoms | 4 |
Related Selumetinib Standards
- Selumetinib Impurity 17 (CAS CATO-C4X-305317)
- Selumetinib Impurity 11 (CAS CATO-C4X-305311)
- Selumetinib Impurity 19 (CAS CATO-C4X-305319)
- Selumetinib Impurity 10 (CAS CATO-C4X-305310)
- Selumetinib Impurity 23 (CAS CATO-C4X-305323)
- Selumetinib Impurity N1 (CAS 606144-02-9)
- Selumetinib Impurity 12 (CAS CATO-C4X-305312)
- Selumetinib Impurity 20 (CAS CATO-C4X-305320)
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