Selumetinib Impurity 12 CAS CATO-C4X-305312
| CAS No. | CATO-C4X-305312 |
| Molecular Formula | C19H18ClFN4O3 |
| Molecular Weight | 404.82 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Selumetinib Impurity 12.
Selumetinib Impurity 12 (CAS CATO-C4X-305312) is a certified pharmaceutical impurity reference standard with the molecular formula C19H18ClFN4O3 and a molecular weight of 404.82 g/mol.
Based on its molecular formula C19H18ClFN4O3, Selumetinib Impurity 12 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 404.82 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Selumetinib Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H18ClFN4O3 |
| Molecular Weight | 404.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Selumetinib Standards
- Selumetinib Impurity 20 (CAS CATO-C4X-305320)
- Selumetinib Impurity N1 (CAS 606144-02-9)
- Selumetinib Impurity 7 (CAS CATO-C4X-30537)
- Selumetinib Impurity 6 (CAS CATO-C4X-30536)
- Selumetinib Impurity 8 (CAS CATO-C4X-30538)
- Selumetinib Impurity 21 (CAS CATO-C4X-305321)
- Selumetinib Impurity 1 (CAS CATO-C4X-30531)
- Selumetinib (CAS 606143-52-6)
Recommended Standards
- 3-(2-Chloro-6-fluorophenyl)-N-[(3,4-dimethoxyphenyl)methyl]-5-methyl-1,2-oxazole-4-carboxamide (CAS 895685-05-9)
- 1-(4-Chloro-2,5-dimethoxyphenyl)-3-(2-methyl-3-(trifluoromethyl)phenyl)thiourea (CAS 2198846-62-5)
- 1-[(2-Chloro-4-fluorophenyl)methoxy]-3-[(2,4,6-trimethylphenyl)methyl]imidazolidine-2,4,5-trione (CAS 303986-56-3)
- 4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile (CAS 871307-18-5)
- Ibuprofen Impurity 80 (CAS 3585-47-5)
- Firocoxib Impurity 1 (CAS CATO-C4X-32111)
- Norepinephrine Impurity 92 (CAS CATO-C4X-151492)
- 1-(2-Bromo-4-fluorobenzyl)-4-methylpiperidine (CAS 1250615-20-3)
- n-(3-Ethoxypropyl)-3,4-dimethylcyclohexan-1-amine (CAS 1342868-70-5)
- (R)-1-Morpholinopropan-2-amine hydrochloride (CAS 1161931-61-8)
- 1-Fluoro-2-iodo-4-(trifluoromethyl)benzene (CAS 110192-48-8)
- N-(3-Aminopropyl)sulfamide (CAS 67104-90-9)
- 2-(Ethylthio)-1-(o-tolyl)-5-(p-tolyl)-1H-imidazole (CAS 1207026-70-7)
- Liraglutide Impurity 21 TFA Salt (CAS CATO-C4X-199221)
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