Lotilaner Impurity 27 (E-Isomer) CAS 2758907-88-7
| CAS No. | 2758907-88-7 |
| Molecular Formula | C17H10Cl3F3O3S |
| Molecular Weight | 457.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Lotilaner Impurity 27 (E-Isomer) (CAS 2758907-88-7), a pharmacopoeial impurity reference standard (molecular formula C17H10Cl3F3O3S, MW 457.68 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Lotilaner Impurity 27 (E-Isomer) (C17H10Cl3F3O3S) is characterized by a steroid core, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Lotilaner Impurity 27 (E-Isomer) under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C17H10Cl3F3O3S |
| Molecular Weight | 457.68 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 1 |
Related Lotilaner Standards
- Lotilaner Impurity 12 (CAS CATO-C4X-325612)
- Lotilaner Impurity 30 (Z-Isomer) (CAS 2758907-89-8)
- Lotilaner Impurity 13 (CAS CATO-C4X-325613)
- Lotilaner Impurity 2 (CAS CATO-C4X-32562)
- Lotilaner Impurity 19 (CAS CATO-C4X-325619)
- Lotilaner Impurity 8 (CAS CATO-C4X-32568)
- Lotilaner Impurity 26 (CAS 2758907-90-1)
- Lotilaner Impurity 3 (CAS CATO-C4X-32563)
Recommended Standards
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com