Clozapine EP Impurity C CAS 6104-71-8
| CAS No. | 6104-71-8 |
| Molecular Formula | C17H17ClN4 |
| Molecular Weight | 312.80 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Clozapine EP Impurity C.
CATO supplies Clozapine EP Impurity C (CAS 6104-71-8), a pharmacopoeial impurity reference standard (molecular formula C17H17ClN4, MW 312.80 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Clozapine EP Impurity C is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 312.80 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Clozapine EP Impurity C meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H17ClN4 |
| Molecular Weight | 312.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Clozapine Standards
Recommended Standards
- tert-butyl 4-[(chlorosulfonyl)(methyl)amino]piperidine-1-carboxylate (CAS 1118788-30-9)
- Tert-butyl n-[1-(6-chloropyrazin-2-yl)piperidin-4-yl]carbamate (CAS 596817-48-0)
- 1-(5-Chloro-2,4-dimethoxyphenyl)-4,4-dimethyl-1,4-dihydropyrimidine-2-thiol (CAS 1142212-65-4)
- tert-Butyl 4-(6-chloro-2-methyl-4-pyrimidinyl)-tetrahydro-1(2H)-pyrazinecarboxylate (CAS 203519-37-3)
- Apremilast impurity 92 (CAS 6744-85-0)
- Policresulen Impurity 18 Ammonium Salt (CAS CATO-C4X-198018)
- Levofloxacin impurity 91 (CAS 151250-74-7)
- 2-Bromo-6-methoxyphenol (CAS 28165-49-3)
- Calcitonin C-Terminal Flanking Peptide (human) XTFA (CAS 85916-47-8（free base）)
- methyl N-[4-(chlorosulfonyl)-2-nitrophenyl]carbamate (CAS 1601259-20-4)
- tert-butyl 3-(aminomethyl)-3-methoxyazetidine-1-carboxylate (CAS 1392804-77-1)
- 3-(2-(4-(4-Fluorophenyl)piperazin-1-yl)-2-oxoethyl)-5-methyl-5-phenylimidazolidine-2,4-dione (CAS 956263-04-0)
- 5-[(2-Fluorophenyl)methyl]-N-methoxy-N-methyl-4-oxo-1H,2H,3H,3aH,4H,5H-pyrrolo[1,2-a]quinoxaline-7-sulfonamide (CAS 1008092-12-3)
- Antistasin-Related Peptide (CAS 161561-46-2)
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