Clozapine Impurity 1 CAS 69414-55-7
| CAS No. | 69414-55-7 |
| Molecular Formula | C13H8Cl2N2O3 |
| Molecular Weight | 311.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Clozapine Impurity 1 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Clozapine Impurity 1 (CAS 69414-55-7), a certified reference material (molecular formula C13H8Cl2N2O3, MW 311.12 g/mol) for analytical method development and quality control.
The molecular framework of Clozapine Impurity 1 (C13H8Cl2N2O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Clozapine Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H8Cl2N2O3 |
| Molecular Weight | 311.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Clozapine Standards
Recommended Standards
- 5-Iodo-6-methyl-2-phenylpyrimidin-4-amine (CAS 83410-20-2)
- N1-(4,6-Dichloropyrimidin-5-yl)-N1-phenyloxalamide (CAS 59808-65-0)
- 4-Chloro-N-(2-chlorophenyl)-3-nitrobenzamide (CAS 97028-19-8)
- Edoxaban Impurity 33 (CAS 349125-14-0)
- (S)-1-(4-fluoro-3-methoxyphenyl)-2-methoxyethan-1-amine (CAS 1269938-03-5)
- 5-(Benzyloxy)-1,2-dimethyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid (CAS 389130-68-1)
- 2-Amino-5,6-dimethylnicotinonitrile (CAS 847060-83-7)
- 1-methyl-3-(methylamino)azepan-2-one hydrochloride (CAS 2059940-37-1)
- Quinidine 1’-Oxide (CAS 115730-97-7)
- Rosuvastatin Impurity 150 (CAS CATO-C4X-1169150)
- 3-Cyclopropoxy-5-fluoro-N-methylpyridin-4-amine (CAS 1243286-08-9)
- Dimethyl 2-((2-chlorothiazol-5-yl)methyl)-2-(2,4-dinitrophenyl)malonate (CAS 861209-93-0)
- 2-Chloro-4-(3-(3,5-dichlorophenyl)ureido)benzene-1-sulfonyl chloride (CAS 680617-69-0)
- Semaglutide Impurity 138 (CAS CATO-C4X-2226138)
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