Lasmiditan Impurity 59 CAS 613677-45-5
| CAS No. | 613677-45-5 |
| Molecular Formula | C20H20F3N3O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Lasmiditan Impurity 59 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Lasmiditan Impurity 59 (CAS 613677-45-5, C20H20F3N3O2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Lasmiditan Impurity 59 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 427.85 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Lasmiditan Impurity 59 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H20F3N3O2 HCl |
| Molecular Weight | 427.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Lasmiditan Standards
- Lasmiditan Impurity 4 (CAS 103640-16-0)
- Lasmiditan Impurity 37 HBr (CAS 1338000-32-0)
- Lasmiditan Impurity 39 (CAS 1347604-52-7)
- Lasmiditan Impurity 19 (CAS 1903-67-9)
- Lasmiditan Impurity 22 (CAS 225112-16-3)
- Lasmiditan Impurity 6 (CAS 28314-80-9)
- Lasmiditan Impurity 32 (CAS 3355-39-3)
- Lasmiditan (CAS 439239-90-4)
Recommended Standards
- Ilaprazole Impurity 171 (CAS CATO-C4X-1130171)
- Palbociclib Impurity 150 (CAS CATO-C4X-1125150)
- Dacomitinib Impurity 22 (CAS 2250242-14-7)
- (1R,2R,3R,4S,5R)-4-amino-5-methylsulfinylcyclopentane-1,2,3-triol (CAS 102822-66-2)
- (4'-Fluorobiphenyl-3-yl)(methyl)sulfane (CAS 748817-99-4)
- Revefenacin impurity 95 (CAS CATO-C4X-203195)
- 1-(6-Chloro-2-methylpyridin-3-yl)ethan-1-amine (CAS 1355179-95-1)
- N-(2-(Cyclopropylamino)cyclohexyl)acetamide (CAS 1353966-04-7)
- 2-(Difluoromethyl)-3-fluoro-4-nitropyridine-6-acetic acid (CAS 1805199-84-1)
- Tau Peptide (273-284) trifluoroacetate salt (CAS 1663490-91-2)
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