Econazole impurity 31 CAS 61622-15-9
| CAS No. | 61622-15-9 |
| Molecular Formula | C8H4Cl4O |
| Molecular Weight | 257.93 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Econazole impurity 31 (CAS 61622-15-9, C8H4Cl4O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Econazole impurity 31 (C8H4Cl4O) contains a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 257.93 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4Cl4O |
| Molecular Weight | 257.93 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
| Halogen Content | Cl-containing |
Related Econazole Standards
- Econazole impurity 30 (CAS CATO-C4X-132730)
- Econazole Impurity 10 (CAS 102993-73-7)
- Econazole impurity 20 (CAS CATO-C4X-132720)
- Econazole impurity 21 (CAS 293759-26-9)
- Econazole impurity 19 (CAS 27523-08-6)
- Econazole Impurity 11 (CAS 4252-78-2)
- Econazole Impurity 5 (CAS 81547-71-9)
- Econazole Impurity 6 (CAS 116865-83-9)
Recommended Standards
- 2,2-dichloro-1-(2,5-dichlorophenyl)ethanone (CAS 2274-68-2)
- 2-Bromo-4,5-dichloro-1-propyl-1H-imidazole (CAS 140187-05-9)
- 3-Iodopentafluoropropene-1 (CAS 431-65-2)
- 4-bromo-3-(bromomethyl)-1-methyl-1H-pyrazole (CAS 1383575-45-8)
- Loteprednol Impurity 6 (CAS CATO-C4X-19576)
- Bisacodyl Impurity 10 (CAS CATO-C4X-203710)
- Tolvaptan Impurity 123 (CAS CATO-C4X-1955123)
- 2-(4-Cyclohexylphenyl)-5,8-dimethoxyquinoline (CAS 860784-10-7)
- [(3aR,6S,6aR)-6-(Benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-5,5-diyl]dimethanol (CAS 63593-03-3)
- 3-(2,5-Dichlorophenyl)piperidine (CAS 1044765-39-0)
- (3R,4S)-4-(m-tolyl)pyrrolidine-3-carboxylic acid hydrochloride (CAS 1049976-06-8)
- (S)-2-Amino-2-(trifluoromethyl)pent-4-enoic acid (CAS 921224-78-4)
- 1-(3-Amino-5-fluoro-4-hydroxyphenyl)ethan-1-one hydrochloride (CAS 2126177-96-4)
- Acetyl tetrapeptide-3 (CAS 827306-88-7)
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