Lobeline impurity 14 CAS 6168-88-3
| CAS No. | 6168-88-3 |
| Molecular Formula | C22H25NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Lobeline impurity 14 (C22H25NO2HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 371.90 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO supplies Lobeline impurity 14 (CAS 6168-88-3), a pharmacopoeial impurity reference standard (molecular formula C22H25NO2HCl, MW 371.90 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H25NO2 HCl |
| Molecular Weight | 371.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Lobeline Standards
- Lobeline impurity 20 (CAS 101113-68-2)
- Lobeline HCl (CAS 134-63-4)
- Lobeline sulfate (CAS 134-64-5)
- Lobeline impurity 16 (CAS 2469224-15-3)
- Lobeline Impurity 2 (CAS 579-21-5)
- Lobeline impurity 17 (CAS 775271-34-6（free base）)
- Lobeline Hydrochloride EP Impurity B (CAS CATO-C1893534)
- Lobeline Hydrochloride EP Impurity A (CAS CATO-C4X-18181)
Recommended Standards
- Vitamin K1 Impurity 14（Z-Isomer) (CAS CATO-C4X-220714)
- Milbemycin Oxime EP Impurity H (CAS 1025877-03-5)
- Nitrendipine Impurity 18 (CAS CATO-C4X-183418)
- 2-(Benzylsulfanyl)-5-[2-(methylsulfanyl)phenyl]-1,3,4-oxadiazole (CAS 339015-40-6)
- n-(4-Formyl-1,3-thiazol-2-yl)-n-(3-methoxyphenyl)acetamide (CAS 872108-10-6)
- (1-Ethyl-5-methyl-1H-pyrazol-4-yl)methanol (CAS 494214-31-2)
- {1-[1-(ethanesulfonyl)piperidin-4-yl]ethyl}(methyl)amine (CAS 1340043-76-6)
- (R,R)(S,S)-Benidipine Hydrochloride (CAS 91599-74-5)
- Tert-butyl 2-(3-aminopiperidin-1-yl)acetate (CAS 1247796-36-6)
- Liraglutide Impurity 16 TFA Salt (CAS CATO-C4X-199216)
Why CATO?
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