Afatinib Impurity 59 CAS 618061-77-1
| CAS No. | 618061-77-1 |
| Molecular Formula | C24H27ClFN4O6P |
| Molecular Weight | 552.92 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Afatinib Impurity 59 (CAS 618061-77-1), molecular formula C24H27ClFN4O6P and molecular weight 552.92 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Afatinib Impurity 59 (C24H27ClFN4O6P) is characterized by a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures Afatinib Impurity 59 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C24H27ClFN4O6P |
| Molecular Weight | 552.92 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Afatinib Standards
- Afatinib Impurity 26 (CAS CATO-C4X-100626)
- Afatinib Impurity 67 (CAS CATO-C4X-100667)
- Afatinib Impurity 48 (CAS 3005278-77-0)
- Afatinib Impurity 8 (CAS CATO-C4X-10068)
- Afatinib Impurity 33 (CAS CATO-C4X-100633)
- Afatinib Impurity 47 (CAS CATO-C4X-100647)
- Afatinib Impurity 23 (CAS CATO-C4X-100623)
- Afatinib Impurity 95 (CAS CATO-C4X-100695)
Recommended Standards
- (S)-Diethyl 2-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-ylamino)-2-oxoethylphosphonate (CAS 618061-76-0)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com